2011 Fiscal Year Final Research Report
Analysis and treatment-application of novel nongenomic action of estrogen receptor mediated by protein deacetylation
| Project/Area Number |
22790882
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Endocrinology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
AZUMA Kotaro 東京大学, 医学部附属病院, 特任講師 (30401110)
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| Project Period (FY) |
2010 – 2011
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| Keywords | エストロゲン受容体 / nongenomic action / 乳癌 / 骨粗鬆症 / 認知症 |
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| Research Abstract |
The aim of this study is to analyze the role of nongenomic action of estrogen receptor in the disease such as breast cancer and osteoporosis, which has relationship with estrogen action. Nongenomic action is newly clarified action of estrogen receptor, which cannot be explained by the formerly-known action of estrogen receptor as a ligand-dependent transcription factor. It was shown that nongenomic action was mediated by estrogen receptor at the plasma membrane instead of estrogen receptor in the nucleus. In this study we demonstrated some genes dependent on the membrane-localizing estrange receptor by using breast cancer cells stably expressing membrane-localizing estrogen receptor. We also established breast cancer cell line expressing both luciferase and membrane-localizing estrogen receptor, which can be a useful tool for evaluating effect of nongenomic action of estrogen receptor on metastatic potential. In this study, we are also preparing osteoblastic cell line expressing membrane-localizing estrogen receptor for evaluating effect of nongenomic action of estrogen receptor on osteoporosis.
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[Journal Article] Clinical significance of steroid and xenobiotic receptor(SXR) and its targeted gene CYP3A4 in human prostate cancer2012
Author(s)
Fujimura T, Takahashi S, Urano T, Tanaka T, Zhang W, Azuma K, Takayama K, Obinata D, Murata T, Horie-Inoue K, Kodama T, OuchiY, Homma Y, Inoue S
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Journal Title
Cancer Sci
Volume: 103
Pages: 176-180
DOI
Peer Reviewed
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