2011 Fiscal Year Final Research Report
Regulatory mechanisms of p27kip1 and its significance by non-genomic action of thyroid hormone.
| Project/Area Number |
22790884
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Endocrinology
|
|---|
| Research Institution | Nagoya University |
|---|
Principal Investigator |
CAO Xia 名古屋大学, 環境医学研究所, 助教 (70432218)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Keywords | 甲状腺ホルモン / ノンゲノミック作用 / p27kip1 |
|---|
| Research Abstract |
T3 inhibited the ubiquitination of p27^<Kip1> the through inducing the Thr187 phospholylation of p27^<Kip1>, and thus enhanced p27^<Kip1> expression. This further promoted the cell differentiation and inhibited cell proliferation.
|
