2011 Fiscal Year Final Research Report
The biological role of BMP-15 in human female reproduction
| Project/Area Number |
22790886
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Endocrinology
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 骨形成蛋白 / 卵胞発育 |
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| Research Abstract |
BMP-15 is a TGF-βsuperfamily member and produced in oocytes within the ovary. BMP-15 has recently been recognized as a candidate factor that may be involved in premature ovarian failure. In this study, BMP-15 mutants identified in premature ovarian failure patients decreased biological activities compared with wild-type, partially due to reduced production of mature protein. Loss of posttranslational phosphorylation of mature BMP-15 also resulted in impaired biological activities. These results are important to elucidate the mechanism in which BMP-15 exerts the various effects on human female reproduction.
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