2011 Fiscal Year Final Research Report
Development of new therapy of cardiovascular disease utilizing specificity of biologically active peptide hormones
| Project/Area Number |
22790891
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Endocrinology
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
TOKUDOME Takeshi 独立行政法人国立循環器病研究センター, 生化学部, 室長 (00443474)
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| Research Collaborator |
SCHWENKE Daryl O. オタゴ大学, 教官
MAO Yuanjie 独立行政法人国立循環器病研究センター, 生化学部, 流動研究員
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| Project Period (FY) |
2010 – 2011
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| Keywords | 内分泌学 / グレリン / ナトリウム利尿ペプチド |
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| Research Abstract |
We recently published that ghrelin(an orexigenic peptide) administration was able to improve malignant arrhythmia-induced mortality in acute myocardial infarction. The present study demonstrated that one dose of ghrelin improves death rate in acute phase and also prevents cardiac remodeling in myocardial infarction. Furthermore, also demonstrated that endogenous ghrelin suppressed arrhythmia-induced death through inhibition of sympathetic nerve activity and activation of parasympathetic nerve activity in acute myocardial infarcti on. These findings suggest potential usefulness of ghrelin as a therapeutic agent in myocardial infarction.
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[Journal Article] Natriuretic Peptide Receptor Guanylyl Cyclase-A Protects Podocytes from Aldosterone-Induced Glomerular Injury2012
Author(s)
Ogawa Y, Mukoyama M, Yokoi H, Ka sahara M, Mori K, Kato Y, Kuwabara T, Imamaki H, Kawanishi T, Koga K, Ishii A, Tokudome T, Kishimoto I, Sugawara A, Nakao K
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Journal Title
Am Soc Nephrol
Volume: (in press)
DOI
Peer Reviewed
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[Journal Article] The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice2012
Author(s)
Fukuhara S, Simmons S, Kawamura S, Inoue A, Orba Y, Tokudome T, Sunden Y, Arai Y, Moriwaki K, Ishida J, Uemura A, Kiyonari H, Abe T, Fukamizu A, Hirashima M, Sawa H, Aoki J, Ishii M, Mochizuk i N
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Journal Title
J Clin Invest
Volume: 122(4)
Pages: 1416-1426
DOI
Peer Reviewed
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[Journal Article] Centrally administered ghrelin activates cardiac vagal nerve in anesthetized rabbits2011
Author(s)
Shimizu S, Akiyama T, Kawada T, Sonobe T, Kamiya A, Shishido T, Tokudome T, Hosoda H, Shirai M, Kangawa K, Sugimachi M
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Journal Title
Auton Neurosci
Volume: 162(1-2)
Pages: 60-65
DOI
Peer Reviewed
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