2011 Fiscal Year Final Research Report
Genome-wide analysis of acute myeloid leukemia using high-density oligonucleotide arrays
| Project/Area Number |
22790900
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
NAKAZAKI Kumi 東京大学, 保健・健康推進本部, 助教 (70550432)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 急性骨髄性白血病 / SNPアレイ / 遺伝子解析 / ゲノム |
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| Research Abstract |
Genome-wide analysis with single nucleotide polymorphisms(SNP) arrays was conducted for samples from 103 cases with acute myeloid leukemia(AML). We applied high-resolution oligonucleotide microarrays(GeneChip(R) 100K or 500K arrays) which enabled us to detect allele specific copy number alterations in tumors systemically and sensitively. As a result, Lots of chromosomal aberrations including very small regions were shown in this study, and uniparental disomy was detected in 29% of AML. Homozygous mutations were highly frequently in UPD regions.
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