Analysis of the mechanism of stem cell and niche-regulating function of refractory leukemia-related molecule, BAALC

2011 Fiscal Year Final Research Report

• Project/Area Number: 22790901
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Hematology
• Research Institution: The University of Tokyo
• Principal Investigator: ICHIKAWA Motoshi 東京大学, 医学部附属病院, 講師 (60463840)
• Project Period (FY): 2010 – 2011
• Keywords: 血液内科学 / 白血病 / 幹細胞

Research Abstract

The BAALC(brain and acute leukemia, cytoplasmic) gene is known to be highly expressed in the acute myeloid leukemia cells with poor prognosis, however, its function in normal and malignant hematopoiesis has not been known. Using gene-targeted mice, this study elucidated a critical role for BAALC in regulating the hematopoietic stem cell niche in the bone marrow through the p53 pathway. These results identified BAALC as a novel stem cell regulating gene, and lead to a molecular targeted therapy for the refractory leukemia.

Research Products

• [Journal Article] The first case of blastic plasmacytoid dendritic cell neoplasm with MLL-ENL rearrangement (2012)
  • Author(s): Toya T, Nishimoto N, Koya J, Nakagawa M, Nakamura F, Kandabashi K, Yamamoto G, Nannya Y, Ichikawa M, Kurokawa M.
  • Journal Title: Leukemia Research Volume: 36 Pages: 117-118
  • DOI: DOI:10.1016/j.leukres.2011.07.029
  • Peer Reviewed
• [Journal Article] Primary MALT lymphoma of the urinary bladder in the background of interstitial cystitis (2012)
  • Author(s): Morita K, Nakamura F, Nannya Y, Nomiya A, Arai S, Ichikawa M, Homma Y, Kurokawa M.
  • Journal Title: Annals of Hematology in press
  • DOI: DOI:10.1007/s00277-012-1419-0
  • Peer Reviewed
• [Journal Article] Fludarabine may overcome resistance to rituximab in IgM-related neuropathy (2012)
  • Author(s): Koya J, Iwata A, Nakamura F, Nagashima Y, Ichikawa M, Tsuji S, Kurokawa M.
  • Journal Title: Journal of the Neurological Sciences Volume: 315 Pages: 150-152
  • DOI: DOI:10.1016/j.jns.2011.12.001
  • Peer Reviewed
• [Journal Article] The clinical role of procalcitonin in hematopoietic SCT (2012)
  • Author(s): Koya J, Nannya Y, Ichikawa M, Kurokawa M.
  • Journal Title: Bone Marrow Transplantation in press
  • DOI: DOI:10.1038/bmt.2012.18
  • Peer Reviewed
• [Journal Article] Evans syndrome with cytomegalovirus infection followed by emerging peripheral T-cell lymphoma. (2012)
  • Author(s): Yamamoto G, Hosoi M, Miyagawa T, Ohmatsu H, Ichikawa M, Sugaya M, Kurokawa M.
  • Journal Title: Annals of Hematology Volume: 91 Pages: 123-124
  • DOI: DOI:10.1007/s00277-011-1214-3
  • Peer Reviewed
• [Journal Article] Temozolomide may induce therapy-related acute lymphoblastic leukaemia (2011)
  • Author(s): Ogura M, Todo T, Tanaka M, Nannya Y, Ichikawa M, Nakamura F, Kurokawa M.
  • Journal Title: British Journal of Haematology Volume: 154 Pages: 663-665
  • DOI: DOI:10.1111/j.1365-2141.2011.08641.x
  • Peer Reviewed
• [Journal Article] Loss of AML1/Runx1 accelerates the development of MLL-ENL leukemia through down-regulation of p19ARF (2011)
  • Author(s): Nishimoto N, Arai S, Ichikawa M, Nakagawa M, Goyama S, Kumano K, Takahashi T, Kamikubo Y, Imai Y, Kurokawa M.
  • Journal Title: Blood Volume: 118 Pages: 2541-2550
  • DOI: DOI:10.1182/blood-2010-10-315440
  • Peer Reviewed
• [Journal Article] Crk-associated substrate lymphocyte type regulates myeloid cell motility and suppresses the progression of leukemia induced by p210Bcr/Abl (2011)
  • Author(s): Seo S, Nakamoto T, Takeshita M, Lu J, Sato T, Suzuki T, Kamikubo Y, Ichikawa M, Noda M, Ogawa S, Honda H, Oda H, Kurokawa M.
  • Journal Title: Cancer Science Volume: 102 Pages: 2109-2117
  • DOI: DOI:10.1111/j.1349-7006.2011.02066.x
  • Peer Reviewed
• [Journal Article] AML1/RUNX1 functions as a cytoplasmic attenuator of NF-κB signaling in the repression of myeloid tumors (2011)
  • Author(s): Nakagawa M, Shimabe M, Watanabe-Okochi N, Arai S, Yoshimi A, Shinohara A, Nishimoto N, Kataoka K, Sato T, Kumano K, Nannya Y, Ichikawa M, Imai Y, Kurokawa M.
  • Journal Title: Blood Volume: 118 Pages: 6626-6637
  • DOI: DOI:10.1182/blood-2010-12-326710
  • Peer Reviewed
• [Journal Article] Composite diffuse large B-cell lymphoma and CD20-positive peripheral T-cell lymphoma (2011)
  • Author(s): Yamazaki S, Fujioka Y, Nakamura F, Ota S, Shinozaki A, Yamamoto G, Kamikubo Y, Nannya Y, Ichikawa M, Fukayama M, Kurokawa M.
  • Journal Title: Pathology International Volume: 61 Pages: 662-666
  • DOI: DOI:10.1111/j.1440-1827.2011.02713.x
  • Peer Reviewed
• [Journal Article] A case of myeloid sarcoma with correlation to JAK2V617F mutation, complicated by myelofibrosis and secondary acute myeloid leukemia (2011)
  • Author(s): Yoshiki Y, Asai T, Ichikawa M, Hangaishi A, Ota S, Imai Y, Takahashi T, Kurokawa M.
  • Journal Title: Internal Medicine Volume: 50 Pages: 2649-2652
  • DOI: DOI:10.2169/internalmedicine.50.5783
  • Peer Reviewed
• [Journal Article] Pure red cell aplasia with follicular lymphoma showing regression and progression parallel to lymphoma (2011)
  • Author(s): Yamamoto G, Maki H, Ichikawa M, Kurokawa M.
  • Journal Title: International Journal of Hematology Volume: 94 Pages: 576-577
  • DOI: DOI:10.1007/s12185-011-0969-6
  • Peer Reviewed
• [Journal Article] Lymphoma with specific affinity to endocrine organs (2011)
  • Author(s): Morita K, Nakamura F, Nannya Y, Kamikubo Y, Ichikawa M, Kurokawa M.
  • Journal Title: Annals of Hematology in press
  • DOI: DOI:10.1007/s00277-011-1372-3
  • Peer Reviewed
• [Journal Article] Haemophagocytic lymphohistiocytosis is a recurrent and specific complication of acute erythroid leukaemia (2011)
  • Author(s): Yamazaki S, Nakamura F, Nasu R, Nannya Y, Ichikawa M, Kurokawa M.
  • Journal Title: British Journal of Haematology Volume: 153 Pages: 669-672
  • DOI: DOI:10.1111/j.1365-2141.2010.08544.x
  • Peer Reviewed
• [Journal Article] Evi-1 is a transcriptional target of mixed-lineage leukemia oncoproteins in hematopoietic stem cells (2011)
  • Author(s): Arai S, Yoshimi A, Shimabe M, Ichikawa M, Nakagawa M, Imai Y, Goyama S, Kurokawa M.
  • Journal Title: Blood Volume: 117 Pages: 6304-6314
  • DOI: DOI:10.1182/blood-2009-07-234310
  • Peer Reviewed
• [Journal Article] Recurrent pericardial effusion after treatment for primary effusion lymphoma-like lymphoma : an autopsied case (2011)
  • Author(s): Kagoya Y. Takahashi T. Yoshimoto T. Ichikawa M. Hangaishi A. Fukayama M. Kurokawa M.
  • Journal Title: Annals of Hematology Volume: 90 Pages: 219-220
  • DOI: DOI:10.1007/s00277-010-0975-4
  • Peer Reviewed
• [Journal Article] Concurrent development of "Burkitt-like" lymphoma and BCL-2-rearranged low-grade B cell lymphoma sharing the same germinal center origin (2011)
  • Author(s): Kobayashi H. Ichikawa M. Hangaishi A. Imai Y. Kurokawa M.
  • Journal Title: International Journal of Hematology Volume: 93 Pages: 112-117
  • DOI: DOI:10.1007/s12185-010-0741-3
  • Peer Reviewed
• [Journal Article] Nilotinib-induced hypothyroidism in a patient with chronic myeloid leukemia (2011)
  • Author(s): Yoshizato T. Nannya Y. Yoshiki Y. Nakamura F. Imai Y. Ichikawa M. Kurokawa M.
  • Journal Title: International Journal of Hematology Volume: 93 Pages: 400-402
  • DOI: DOI:10.1007/s12185-011-0790-2
  • Peer Reviewed
• [Journal Article] Disseminated tuberculosis following unrelated cord blood transplantation for refractory peripheral T-cell lymphoma : Clinical role of serum procalcitonin levels (2011)
  • Author(s): Koya J. Nannya Y. Yoshizato T. Ono K. Seo S. Nakagawa M. Ichikawa M. Kurokawa M.
  • Journal Title: Journal of Infection Volume: 62 Pages: 237-240
  • DOI: DOI:10.1016/j.jinf.2011.01.010
  • Peer Reviewed
• [Journal Article] Postremission gemtuzumab ozogamicin for elderly patients with acute myelogenous leukemia with favorable characteristics and comorbid conditions (2010)
  • Author(s): Ichikawa M. Hangaishi A. Nannya Y. Kurokawa M.
  • Journal Title: International Journal of Hematology Volume: 92 Pages: 673-674
  • DOI: DOI:10.1007/s12185-010-0711-9
  • Peer Reviewed
• [Journal Article] FDG-PET is effective in the detection of granulocytic sarcoma in patients with myeloid malignancy (2010)
  • Author(s): Ueda K. Ichikawa M. Takahashi M. Momose T. Ohtomo K. Kurokawa M.
  • Journal Title: Leukemia Research Volume: 34 Pages: 1239-1241
  • DOI: DOI:10.1016/j.leukres.2010.04.017
  • Peer Reviewed
• [Journal Article] AML1 enhances the expression of leukotriene B4 type-1 receptor in leukocytes (2010)
  • Author(s): Hashidate T. Murakami N. Nakagawa M. Ichikawa M. Kurokawa M. Shimizu T. Nakamura M.
  • Journal Title: FASEB Journal Volume: 24 Pages: 3500-3510
  • DOI: DOI:10.1096/fj.10-156844
  • Peer Reviewed
• [Journal Article] T cell acute lymphoblastic leukemia arising from familial platelet disorder (2010)
  • Author(s): Nishimoto N. Imai Y. Ueda K. Nakagawa M. Shinohara A. Ichikawa M. Nannya Y. Kurokawa M.
  • Journal Title: International Journal of Hematology Volume: 92 Pages: 194-197
  • DOI: DOI:10.1007/s12185-010-0612-y
  • Peer Reviewed
• [Journal Article] A case of anaplastic large cell lymphoma, ALK positive, primary presented in the skin and relapsed with systemic involvement and leukocytosis after years of follow-up period (2010)
  • Author(s): Hosoi M. Ichikawa M. Imai Y. Kurokawa M.
  • Journal Title: International Journal of Hematology Volume: 92 Pages: 667-668
  • DOI: DOI:10.1007/s12185-010-0708-4
  • Peer Reviewed
• [Presentation] Use of second generation tyrosine kinase inhibitors for imatinib-induced renal dysfunction (2011)
  • Author(s): 市川幹, ほか2名
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋市
  • Year and Date: 2011-10-15
• [Presentation] Postremission gemtuzumab ozogamicin in older patients with AML : a single-center study (2010)
  • Author(s): 市川幹, ほか2名
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: 横浜市
  • Year and Date: 2010-09-25