2011 Fiscal Year Final Research Report
Research for regulatory mechanisms of normal hematopoietic stem cell and leukemia stem cell pool via mTOR Complex 1
| Project/Area Number |
22790906
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | Kanazawa University |
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Principal Investigator |
HOSHII Takayuki 金沢大学, がん進展制御研究所, 助教 (20464042)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 幹細胞 / シグナル伝達 / mTOR複合体 |
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| Research Abstract |
Although dysregulation of mTOR complex 1(mTORC1) promotes leukemogenesis, how mTORC1 affects established leukemia is unclear. We investigated the role of mTORC1 in mouse model of acute myeloid leukemia. Raptor deficiency significantly suppressed leukemia progression by causing apoptosis of differentiated, but not undifferentiated, leukemia cells. Strikingly, a subset of AML cells with undifferentiated phenotypes survived long-term in the absence of mTORC1 activity. Thus, AML cells lacking mTORC1 activity can self-renew as AML stem cells.
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