2012 Fiscal Year Final Research Report
The molecular mechanism of prognostic exacerbation by the addition of KIT mutations in CBF leukemia
| Project/Area Number |
22790911
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | CBF 白血病 / KIT 遺伝子変異 / 薬剤耐性遺伝子 / DNA 修復遺伝子 |
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| Research Abstract |
Core binding factor (CBF) acute myeloid leukemia (AML) has a relatively favorable prognosis. However, activating KIT mutations are reported to be associated with higher risk of relapse and shorter survival. This project aims to clarify the molecular mechanism of such unfavorable effects by KIT mutations. The applicant explained that KIT mutations give poor prognosis to CBF leukemia through the induction of drug resistance genes and the reduction of DNA repair-related genes.
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