2011 Fiscal Year Final Research Report
Functional analysis of autophagy in T cells of healthy donors and SLE patients
| Project/Area Number |
22790924
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 膠原病学 |
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| Research Abstract |
We successfully developed the high thorough-put and high sensitive method to measure autophagic activity of human activated T cells on flow cytometry. Using this method, we analysed the functional significance of autophagy for stress by cell replication, drugs. We confirmed that autophagy had inhibitory effects on apoptotic cell death of activated T cells.
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