2011 Fiscal Year Final Research Report
The role of Ikaros family proteins n Th17 cell differentiation
| Project/Area Number |
22790925
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Chiba University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | ヘルパーT細胞分化 / Ikarosファミリー分子 / Helios / 制御性T細胞 |
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| Research Abstract |
We have recently shown that Helios, an Ikaros family of transcription factor, is highly expressed in CCR6+CD4+CD45RO+ T cells as compared with that in CCR6-CD4+CD45RO+ T cells. However, the role of Helios in T cell differentiation remains largely unknown. Therefore, in this study, we examined the role of Helios in the differentiation of murine CD4+ T cells. We first examined the effect of various cytokines on the expression of Helios in TCR-stimulated murine splenic CD4+ T cells and found that TGF-β induced Helios expression in CD4+ T cells. In contrast, IL-6 inhibited Helios expression in a Stat3-dependent manner. Retroviral-mediated expression of Foxp3 in the absence of TGF-β did not induce Helios expression in CD4+ T cells. On the other hand, enforced expression of Helios up-regulated activation markers of regulatory T cells (Tregs) such as CD103 and GITR in Foxp3+ Tregs. These results suggest that TGF-β may enhance Treg function through the induction of Helios expression in a Foxp3-independent fashion.
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Research Products
(10 results)
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[Journal Article] lymphocyte attenuator suppresses IL-21 production from follicular Th cells and subsequent humoral immune responses2010
Author(s)
Kashiwakuma D, Suto A, Hiramatsu Y, Ikeda K, Takatori H, Suzuki K, Kagami S, Hirose K, Watanabe N, Iwamoto I, Nakajima H., B, T
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Journal Title
J Immunol
Volume: 185(5)
Pages: 2730-6
DOI
Peer Reviewed
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[Journal Article] Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation2010
Author(s)
Wei L, Vahedi G, Sun HW, Watford WT, Takatori H, Ramos HL, Takahashi H, Liang J, Gutierrez-Cruz G, Zang C, Peng W, O'Shea JJ, Kanno Y
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Journal Title
Immunity
Volume: 32(6)
Pages: 840-51
DOI
Peer Reviewed
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