2011 Fiscal Year Final Research Report
Development of antigen specific therapy for rheumatoid arthritis
| Project/Area Number |
22790926
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SHODA Hirofumi 東京大学, 医学部附属病院, 助教 (20529036)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 関節リウマチ / 新規治療法 / T細胞 |
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| Research Abstract |
We identified autoantigen BiP-derived HLA-DR4 epitopes in rheumatoid arthritis(RA) patients. BiP-specific CD4+T cells increased both in peripheral blood and synovial tissues of RA. This subset produced pro-inflammatory cytokine, interleukin(IL)-17, and could have a close association with RA pathogenesis. Moreover, oral administration of this BiP epitope ameliorated mouse models of RA significantly. These observations support the possibility of the development of antigen-specific therapy for RA.
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