2011 Fiscal Year Final Research Report
Exploration of signal transduction mechanism of TSLP aiming at developing a novel therapy for allergic disorders
| Project/Area Number |
22790935
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Saga University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | アレルギー学 / サイトカイン |
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| Research Abstract |
Thymic stromal lymphopoietin(TSLP) is a cytokine that plays an important role in the development of allergic inflammation. It was shown to activate human dendritic cells to promote Th2-type immune response. We examined the detailed signal transduction mechanism of TSLP. The multiple signal pathways activated by TSLP were selectively down-regulated by the Th1-inducing agents such as TLR ligands. Furthermore, we successfully established a cell line that demonstrates activation of the similar signal pathways by TSLP to those in dendritic cells. This cell line will be of great help in analyzing biochemical properties of the TSLP signal transduction
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[Journal Article] a matricellular protein, plays a role in the induction of chemokines in pulmonary fibrosis2012
Author(s)
Uchida M, Shiraishi H, Ohta S, Arima K, Taniguchi K, Suzuki S, Okamoto M, Ahlfeld SK, Ohshima K, Kato S, Toda S, Sagara H, Aizawa H, Hoshino T, Conway SJ, Hayashi S, Izuhara K. Periostin
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Journal Title
Am J Respir Cell Mol Biol
Volume: (Epub ahead of print)
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[Journal Article] a matricellular protein, accelerates cutaneous wound repair by activating dermal fibroblasts2012
Author(s)
Ontsuka K, Kotobuki Y, Shiraishi H, Serada S, Ohta S, Tanemura A, Yang L, Fujimoto M, Arima K, Suzuki S, Murota H, Toda S, Kudo A, Conway SJ, Narisawa Y, Katayama I, Izuhara K, Naka T. Periostin
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Journal Title
Exp Dermatol
Volume: 21
Pages: 331-336
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[Journal Article] Thymic stromal lymphopoietin-activated plasmacytoid dendritic cells induce the generation of forkhead box P3^+ regulatory T cells in human thymus2010
Author(s)
Hanabuchi S, Ito T, Park WR, Watanabe N, Shaw JL, Roman E, Arima K, Wang YH, Voo KS, Cao W, Liu YJ
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Journal Title
J Immunol
Volume: 184
Pages: 2999-3007
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[Journal Article] Endotoxin tolerance attenuates airway allergic inflammation in model mice by suppression of the T-cell stimulatory effect of dendritic cells2010
Author(s)
Matsushita H, Ohta S, Shiraishi H, Suzuki S, Arima K, Toda S, Tanaka H, Nagai H, Kimoto M, Inokuchi A, Izuhara K
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Journal Title
Int Immunol
Volume: 22
Pages: 739-747
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[Patent(Industrial Property Rights)] 慢性副鼻腔炎の検出方法2011
Inventor(s)
出原賢治,太田昭一郎,有馬和彦,白石裕士,鈴木章一,太田伸男,石田晃弘,鈴木祐輔
Industrial Property Rights Holder
出原賢治,太田昭一郎,有馬和彦,白石裕士,鈴木章一,太田伸男,石田晃弘,鈴木祐輔
Industrial Property Number
特願、2011-238913
Filing Date
2011-10-31
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