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2013 Fiscal Year Final Research Report

Analysis of human Th17/Th21 cells in allergy and autoimmune diseases

Research Project

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Project/Area Number 22790940
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionSaitama Medical University

Principal Investigator

TAKAGI Rie  埼玉医科大学, 医学部, 助手 (00569080)

Project Period (FY) 2010-04-01 – 2014-03-31
Keywordsアレルギー学
Research Abstract

Allergic airway inflammation is generally considered to be a Th2-type immune response. Recent studies, however, have demonstrated that Th17-type immune responses also play important roles in this process, particularly in the pathogenesis of neutrophilic airway inflammation, a hallmark of severe asthma. We therefore evaluated whether wogonin suppresses OVA-induced neutrophilic airway inflammation in OVA TCR-transgenic DO11.10 mice. Consequently, oral administrationof wogonin significantly improved OVA-induced neutrophilic airway inflammation. Wogonin suppressed the differentiation of naive T cells to Th17 cells, while showing no effects on activated Th17 cells.

  • Research Products

    (7 results)

All 2013 2011 2010 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (1 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Qualitative evaluation of adjuvant activities and its application to Th2/17 diseases2011

    • Author(s)
      Matsushita, S., Takagi, R., Hashimoto, K., Higashi, T.
    • Journal Title

      Int. Arch. Allergy Immunol

      Volume: 155(suppl.1) Pages: 2-5

    • Peer Reviewed
  • [Journal Article] Coenzyme A contained in mothers' milk is associated with the potential to induce atopic dermatitis2011

    • Author(s)
      Higashi, T., Shimojo, N., Suzuki, S., Nakaya, M., Takagi, R., Hashimoto, K., Nakagome, K., Nakamura, K., Kohno, Y. and Matsushita, S.
    • Journal Title

      Int. Immunol

      Volume: 23 Pages: 741-749

    • Peer Reviewed
  • [Journal Article] Curdlan induces DC-mediated Th17 polarization via Jagged1 activation in human dendritic cells2010

    • Author(s)
      Higashi T, Hashimoto K, Takagi R, Mizuno Y, Okazaki Y, Tanaka Y and Matsushita S.
    • Journal Title

      Allergol. Int.

      Volume: 59 Pages: 161-166

    • Peer Reviewed
  • [Journal Article] Wogonin attenuates ovalbumin antigen-induced neutrophilic airway inflammation by inhibiting Th17 differentiation

    • Author(s)
      Takagi, R., Kawano, M., Nakagome, K., Hashimoto, K., Higashi, T., Ohbuchi, K., Kaneko, A. and Matsushita, S.
    • Journal Title

      Int. J. Inflamm.

      Volume: (in press)

    • Peer Reviewed
  • [Presentation] オウゴニンはドーパミンD1受容体アンタゴニストであり好中球性気道炎症を抑制する2013

    • Author(s)
      高木理英, 川野雅章, 中込一之, 橋本久実子, 東丈裕, 大渕勝也, 金子篤, 松下祥
    • Organizer
      第63回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2013-11-28
  • [Book] Th17 細胞の産生ケモカインとその意義2010

    • Author(s)
      松下 祥,高木理英
    • Total Pages
      229-234
    • Publisher
      臨床免疫・アレルギー科
  • [Remarks]

    • URL

      http://www.saitama-med.ac.jp/uinfo/meneki/index.html

URL: 

Published: 2015-06-25  

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