Roles of IL-17 family cytokines in airway hyper responses

2012 Fiscal Year Final Research Report

• Project/Area Number: 22790944
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: The University of Tokyo
• Principal Investigator: NAMBU Aya 東京大学, 医科学研究所, 特任研究員 (10456197)
• Project Period (FY): 2010 – 2012
• Keywords: 免疫 / サイトカイン

Research Abstract

In this study I had tried to understand the roles of IL-25 and IL17B in a airway hyper responses (AHR). In a mouse model of allergic AHR, IL-17E derived from epithelial cells has a critical role by recruiting eosinophils to local inflammation sites.

Research Products

• [Journal Article] Epithelial cell-derived IL-25, but not Th17 cell-derived IL-17 or IL-17F, is crucial for murine asthma. (2012)
  • Author(s): Suzukawa M, Morita H, Nambu A, Arae K,Shimura E, Shibui A, Yamaguchi S, Suzukawa K, Nakanishi W, Oboki K, Kajiwara N, Ohno T, Ishii A, Korner H, Cua DJ, Suto H,Yoshimoto T, Iwakura Y, Yamasoba T, Ohta K, Sudo K, Saito H, Okumura K, Broide DH,Matsumoto K, Nakae S.
  • Journal Title: J immunol. Volume: 189(7) Pages: 3641-52
  • DOI: DOI:10.4049/jimmunol.1200461
• [Journal Article] Th17 cell-derived IL-17 is dispensable forB cell antibody production. (2012)
  • Author(s): Shibui A, Shimura E, Nambu A, Yamaguchi S, Leonard WJ, Okumura K, Sugano S, Sudo K, Nakae S.
  • Journal Title: Cytokine. Volume: 59(1) Pages: 108-14
  • DOI: DOI:10.1016/j.cyto.2012.03.018
• [Journal Article] Alteration of immune responses by N-acetylglucosaminyltransferase V during allergic airway inflammation. (2011)
  • Author(s): Shibui A, Nambu A, Shimura E, Yamaguchi S, Shiraishi C, Sato Y, Okumura K, Sugano S, Hozumi N, Nakae S.
  • Journal Title: Allergol Int. Volume: 60(3) Pages: 345-54
  • DOI: DOI:10.2332/allergolint.10-OA-0283
• [Journal Article] Fischbein MPInterleukin-17 accelerates allograft rejection by suppressing regulatory T cell expansion. (2011)
  • Author(s): Itoh S, Kimura N, Axtell RC, Velotta JB, Gong Y, Wang X, Kajiwara N, Nambu A, Shimura E, Adachi H, Iwakura Y, Saito H, Okumura K, Sudo K, Steinman L, Robbins RC, Nakae S
  • Journal Title: Circulation Volume: 24(11 Suppl) Pages: S187-96
  • DOI: DOI:10.1161/CIRCULATIONAHA.110.014852
• [Journal Article] IL-33 is a crucial amplifier of innate rather than acquired immunity. (2010)
  • Author(s): Oboki K, Ohno T, Kajiwara N, Arae K, Morita H, Ishii A, Nambu A, Abe T, KiyonariH, Matsumoto K, Sudo K, Okumura K, SaitoH, Nakae S.
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 107(43) Pages: 18581-6
  • DOI: DOI:10.1073/pnas.1003059107
• [Journal Article] Development of IL-17-mediated delayed-type hypersensitivity is not affected by down-regulation of IL-25 expression. (2010)
  • Author(s): Ishii A, Oboki K, Nambu A, Morita H, OhnoT, Kajiwara N, Arae K, Sudo H, Okumura K, Saito H, Nakae S.
  • Journal Title: Allergol Int. Volume: 59(4)7 Pages: 399-408
  • DOI: DOI:10.2332/allergolint.10-OA-0218
• [Presentation] Regulation and function of IL-16 (2010)
  • Author(s): 南部あや、角木基彦、中江進
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸
  • Year and Date: 20101207-10