Characterization of a novel HIV-2 circulating recombinant form CRF01_AB

2011 Fiscal Year Final Research Report

• Project/Area Number: 22790962
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Infectious disease medicine
• Research Institution: National Hospital Organization Nagoya Medical Center
• Principal Investigator: IBE Shiro 独立行政法人国立病院機構(名古屋医療センター臨床研究センター), 感染・免疫研究部, 研究員 (10399595)
• Project Period (FY): 2010 – 2011
• Keywords: ウイルス / 感染症

Research Abstract

Viral production of HIV-2 CRF01_AB isolates was 10-to 100-fold higher than that of HIV-2 group A and B isolates. Furthermore, a severe cytopathic effect was observed in HIV-2 CRF01_AB-infected cells. As the findings would explain in part the high pathogenicity of HIV-2 CRF01_AB, further detailed characterization of the virus would be the next important study.

Research Products

• [Journal Article] Cellular HIV-1 DNA levels in patients receiving antiretroviral therapy strongly correlate with therapy initiation timing but not with therapy duration (2011)
  • Author(s): Watanabe D, Ibe S, Uehira T, Minami R, Sasakawa A, Yajima K, Yonemoto H, Bando H, Ogawa Y, Taniguchi T, Kasai D, Nishida Y, Yamamoto M, Kaneda T, Shirasaka T.
  • Journal Title: BMC Infect Dis Volume: 11 Pages: 146
  • DOI: doi:10.1186/1471-2334-11-146
  • Peer Reviewed
• [Journal Article] 世界最初のHIV-2組換え流行株CRF01_ABの発見 (2011)
  • Author(s): 伊部史朗
  • Journal Title: 日本エイズ学会誌 Volume: 13 Pages: 76-82
• [Journal Article] Clinical significance of HIV reverse-transcriptase inhibitor-resistance mutations (2011)
  • Author(s): Ibe S, Sugiura W.
  • Journal Title: Future Microbiol Volume: 6 Pages: 295-315
  • DOI: doi:10.2217/fmb.11.7
  • Peer Reviewed
• [Journal Article] Outbreak of hepatitis B virus genotype A and transmission of genetic drug resistance in cases coinfected with HIV-1 in Japan (2011)
  • Author(s): Fujisaki S, Yokomaku Y, Shiino T, Koibuchi T, Hattori J, Ibe S, Iwatani Y, Iwamoto A, Shirasaka T, Hamaguchi M, Sugiura W.
  • Journal Title: J Clin Microbiol Volume: 49 Pages: 1017-1024
  • DOI: doi:10.1128/JCM.02149-10
  • Peer Reviewed
• [Journal Article] Trends in transmitted drug-resistant HIV-1 and demographic characteristics of newly diagnosed patients : nationwide surveillance from 2003 to 2008 in Japan (2010)
  • Author(s): Hattori J, Shiino T, Gatanaga H, Yoshida S, Watanabe D, Minami R, Sadamasu K, Kondo M, Mori H, Ueda M, Tateyama M, Ueda A, Kato S, Ito T, Oie M, Takata N, Hayashida T, Nagashima M, Matsuda M, Ibe S, Ota Y, Sasaki S, Ishigatsubo Y, Tanabe Y, Koga I, Kojima Y, Yamamoto M, Fujita J, Yokomaku Y, Koike T, Shirasaka T, Oka S, Sugiura W.
  • Journal Title: Antiviral Res Volume: 88 Pages: 72-79
  • DOI: doi:10.1016/j.antiviral.2010.07.008
  • Peer Reviewed
• [Journal Article] HIV-2 CRF01_AB : first circulating recombinant form of HIV-2 (2010)
  • Author(s): Ibe S, Yokomaku Y, Shiino T, Tanaka R, Hattori J, Fujisaki S, Iwatani Y, Mamiya N, Utsumi M, Kato S, Hamaguchi M, Sugiura W.
  • Journal Title: J Acquir Immune Defic Syndr Volume: 54 Pages: 241-247
  • DOI: doi:10.1097/QAI.0b013e3181dc98c1
  • Peer Reviewed
• [Journal Article] 本邦におけるHIV-2の疫学動向と新たな組換え流行株CRF01_ABの同定 (2010)
  • Author(s): 伊部史朗、横幕能行、杉浦亙
  • Journal Title: 病原微生物検出情報 Volume: 31 Pages: 232-233
  • URL: http://idsc.nih.go.jp/iasr/31/366/dj3664.html
• [Presentation] Drug-resistance profiles of HIV-2 CRF01_AB-infected case during abacavir+lamivudine+lopinavir/r therapy (2011)
  • Author(s): Ibe S, Yokomaku Y, Maejima M, Iwatani Y, Sugiura W
  • Organizer: 6th German-Japanese HIV Symposium
  • Place of Presentation: Bochum, Germany
  • Year and Date: 20111100
• [Presentation] ウェスタンブロット法によりHIV-1/HIV-2重複感染が疑われた症例の精査解析 (2011)
  • Author(s): 伊部史朗,近藤真規子,今村淳治,岩谷靖雅,横幕能行,杉浦亙
  • Organizer: 第25回日本エイズ学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 20111100
• [Presentation] Identification of novel drug-resistance mutations selected during abacavir+lamivudine+lopinavir/r therapy in HIV-2 CRF01_AB infection (2011)
  • Author(s): Ibe S, Masaoka T, Yokomaku Y, Iwatani Y, Sugiura W
  • Organizer: International Union of Microbiological Societies 2011 Congress
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 20110900
• [Presentation] 抗レトロウイルス療法中のHIV-2 CRF01_AB感染症例に認めた薬剤耐性変異 (2011)
  • Author(s): 伊部史朗,正岡崇,横幕能行,岩谷靖雅,杉浦亙
  • Organizer: 第13回白馬シンポジウム
  • Place of Presentation: 札幌
  • Year and Date: 20110500
• [Presentation] 抗レトロウイルス治療中のHIV-2 CRF01_AB感染症例に認めた薬剤耐性変異 (2011)
  • Author(s): 伊部史朗,横幕能行,服部純子,杉浦亙
  • Organizer: 第85回日本感染症学会総会
  • Place of Presentation: 東京
  • Year and Date: 20110400
• [Presentation] First case of HIV-2 CRF01_AB infection treated with combination antiretroviral therapy (2010)
  • Author(s): Ibe S, Yokomaku Y, Hattori J, Iwatani Y, Sugiura W.
  • Organizer: 11th Annual Symposium on Antiviral Drug Resistance
  • Place of Presentation: Hershey, USA
  • Year and Date: 20101100
• [Presentation] 抗レトロウイルス療法のモニタリングのためのplasma HIV-2 viral load測定系の確立 (2010)
  • Author(s): 伊部史朗,横幕能行,服部純子,岩谷靖雅,加藤真吾,杉浦亙
  • Organizer: 第24回日本エイズ学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 20101100
• [Presentation] Development of a highly sensitive and reproducible plasma HIV-2 RNA copy quantification method for monitoring antiretroviral treatment (2010)
  • Author(s): Ibe S, Yokomaku Y, Tanaka R, Hattori J, Fujisaki S, Iwatani Y, Kato S, Hamaguchi M, Sugiura W
  • Organizer: XVIII International AIDS Conference
  • Place of Presentation: Vienna, Austria
  • Year and Date: 20100700
• [Presentation] Molecular epidemiology of HIV-2 in Japan : identification of the first circulating recombinant form of HIV-2, CRF01_AB (2010)
  • Author(s): Ibe S, Yokomaku Y, Shiino T, Tanaka R, Hattori J, Fujisaki S, Iwatani Y, Mamiya N, Utsumi M, Kato S, Hamaguchi M, Sugiura W.
  • Organizer: 5th International Workshop on HIV Transmission
  • Place of Presentation: Vienna, Austria
  • Year and Date: 20100700
• [Presentation] 定量PCR法を用いたHIV-2 viral load測定系の確立とその臨床応用 (2010)
  • Author(s): 伊部史朗,横幕能行,服部純子,杉浦亙
  • Organizer: 第84回日本感染症学会総会
  • Place of Presentation: 京都
  • Year and Date: 20100400