2011 Fiscal Year Final Research Report
The study of graft-versus-leukemia effect of cord blood NK cells Against refractory childhood leukemia
| Project/Area Number |
22790971
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | University of Yamanashi |
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Principal Investigator |
OHSHIRO Hiroko 山梨大学, 医学部・附属病院, 助教 (50377537)
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| Project Period (FY) |
2010 – 2011
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| Keywords | NK細胞 / 急性リンパ性白血病 / 臍帯血移植 / KIRリガンド不一致 |
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| Research Abstract |
Acute lymphoblastic leukemia(ALL) with 11q23 translocation is associated with an extremely poor prognosis despite intensive chemotherapy and hematopoietic stem cell transplantation(SCT). In recent years, it has been postulated that NK cells can play a role in reducing disease recurrence through GVL(graft-versus leukemia) effect. ALL cells with 11q23 translocation are sensitive to killing by KIR(major NK receptors) ligand incompatible cord blood-NK cells, and therefore the GVL effect against this leukemia could be considerably expected if the KIR ligand incompatible donor is selected for CBT.
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