2011 Fiscal Year Final Research Report
The role of integrin for pediatric peritoneal sclerosis
| Project/Area Number |
22790985
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Pediatrics
|
|---|
| Research Institution | The University of Tokushima |
|---|
Principal Investigator |
SUGA Kenichi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 非常勤講師 (70511335)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Keywords | インテグリン / 腹膜硬化症 / 小児 |
|---|
| Research Abstract |
The extracellular matrix(ECM) and integrins increased on the encapsulating peritoneal sclerosis(EPS) model rat. ECM proteins and integrins increased when tumor growth factor-β(TGF-β) stimulated the cultured peritoneal fibroblasts. These results suggest that integrins enhanced by TGF-βmight contribute EPS development through the abnormal ECM remodeling.
|
