2011 Fiscal Year Final Research Report
Analysis of molecular function of CCL8 as a biomarker for acute graft-versus-host disease
| Project/Area Number |
22790990
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 移植片対宿主病 / バイオマーカー / ケモカイン / 造血幹細胞移植 / マウスモデル |
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| Research Abstract |
We studied about chemokine CCL8 as a biomarker of acute graft-versus-host disease(GVHD). The plasma CCL8 concentration in GVHD mouse model showed correlated with the severity and the prognosis of GVHD mice. Similarly, serum CCL8 concentration may reflect the response to the treatment against GVHD and correlate with the severity of GVHD in human.
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[Journal Article] Early expression of plasma CCL8 closely correlates with survival rate of acute graft-vs2011
Author(s)
Yamamoto M, Ota A, Hori T, Imai S, Sohma H, Suzuki N, Hatakeyama N, Inazawa N, Ito YM, Kimura H, Tsutsumi H, Kokai Y
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Journal Title
Experimental Hematology
Volume: 39
Pages: 1101-1112
DOI
Peer Reviewed
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