2011 Fiscal Year Final Research Report
Analysis of the maintenance mechanism of slit diaphragm, essential structure for glomerular filtration in kidney
Project/Area Number |
22790991
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Pediatrics
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Research Institution | The University of Tokyo (2011) Yokohama City University (2010) |
Principal Investigator |
HARITA Yutaka 東京大学, 医学部附属病院, 講師 (10451866)
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Project Period (FY) |
2010 – 2011
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Keywords | 小児腎 / 泌尿器学 |
Research Abstract |
We analyzed how the Par-aPKC polarity complex is involved in the maintenance of slit diaphragm structure, the intercellular junctional complex responsible for the glomerular filtration barrier, and in the downstream signaling pathway. We found that slit diaphragm components are rapidly endocytosed and exocytosed and PAR-aPKC regulates exocytosis of Nephrin. This result unravels the mechanism of formation and maintenance of slit diaphragm, which is necessary for the prevention of proteinuria.
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Research Products
(24 results)
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[Journal Article] Renal manifestations, progression and pathological findings in patients with R702 mutations in MYH92010
Author(s)
SekineT, Konno M, Sasaki S, Moritani Sm Miura T, Wong WS, Nishio H Nishiguchi T, Yoshinari M, Tsuchiya S, Matsuyama T, Kanegane H, Ida K, Miura K, Harita Y, Igarashi T, Hattori M, Horita S, Saito H, Kunishima S
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Journal Title
Kidney Int
Volume: 78(2)
Pages: 207-14
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[Journal Article] Glomerular proteins related to slit diaphragm and matrix adhesion in the foot processes are highly tyrosine phosphorylated in the normal rat kidney2010
Author(s)
Zhang Y, Yoshida Y, Nameta M, Xu B, Taguchi I, Ikeda T, Fujinaka H, Mohamed SM, Tsukaguchi H, Harita Y, Yaoita E, Yamamoto T
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Journal Title
Nephrol Dial Transplant
Volume: 25(6)
Pages: 1785-95
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