2011 Fiscal Year Final Research Report
Diclofenac enhances proinflammatory cytokine-induced phagocytosis through nitric oxide production in cultured microglia
| Project/Area Number |
22790993
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Nagoya City University |
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Principal Investigator |
KAKITA Hiroki 名古屋市立大学, 大学院・医学研究科, 助教 (40528949)
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| Project Period (FY) |
2010 – 2011
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| Keywords | インフルエンザ脳症 / グリア細胞 / ジクロフェナック / 一酸化窒素 |
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| Research Abstract |
this study demonstrates that iNOS and NO are induced in microglia cultures by proinflammatory cytokines. The addition of DCF further augments NO production. This effect is mediated via NF-B signaling and induced microglia activity and phagocytosis.
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Research Products
(4 results)
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[Journal Article] Endogenous erythropoietin from astrocyte protects the oligodendrocyte precursor cell against hypoxic and reoxygenation injury2011
Author(s)
Kato S, Aoyama M, Kakita H, Hida H, Kato I, Ito T, Goto T, Hussein M, Sawamoto K, Togari H, Asai K.
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Journal Title
J Neurosci Res
Volume: 89
Pages: 1566-74
DOI
Peer Reviewed
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