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2012 Fiscal Year Final Research Report

Analysis on mechanism that translocates p27Kip1 into nuclei in neuronal progenitor cells in vivo

Research Project

  • PDF
Project/Area Number 22791001
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionKeio University

Principal Investigator

MITSUHASHI Takayuki  慶應義塾大学, 医学部, 講師 (80338110)

Project Period (FY) 2010 – 2012
Keywords神経発生 / 細胞周期 / プロモータ / 神経幹細胞 / 大脳皮質
Research Abstract

p27Kip1, one of the cell cycle regulatory genes, play a critical role in differentiation of neuronal progenitor cells (NPCs). A purpose of this research was to elucidate the mechanism controlling nuclear accumulation of p27Kip1 proteins. We conducted immu

  • Research Products

    (6 results)

All 2012 2011 2010 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (3 results) Book (1 results) Remarks (1 results)

  • [Journal Article] In utero exposure to dioxin causes neocortical dysgenesis through the actions of p27Kip12010

    • Author(s)
      Mitsuhashi T, Yonemoto J, Sone H, Kosuge Y, Kosaki K, Takahashi T
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 107巻 Pages: 16331-16335

    • Peer Reviewed
  • [Presentation] In utero exposure to dioxin causes neocortical dysgenesis through the actions of p27Kip12011

    • Author(s)
      Mitsuhashi T, Yonemoto J, Sone H, Kosuge Y, Kosaki K, Takahashi T
    • Organizer
      The 41st annual meeting for Society for Neuroscience
    • Place of Presentation
      Washington, D.C., USA
    • Year and Date
      2011-11-14
  • [Presentation] 胎内でのダイオキシン曝露は大脳皮質深層の投射ニューロン産生を障害し皮質を菲薄化させる2011

    • Author(s)
      三橋隆行、高橋孝雄
    • Organizer
      第53回日本小児神経学会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-05-27
  • [Presentation] ダイオキシン胎内曝露によるp27Kip1 を介した大脳皮質構築異常:数学モデルを用いた解析2010

    • Author(s)
      三橋隆行
    • Organizer
      第41回慶應ニューロサイエンス研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-06
  • [Book] 発達科学入門2 胎児期~児童期2012

    • Author(s)
      三橋隆行、吉井聡、高橋孝雄
    • Total Pages
      3-19
    • Publisher
      東京大学出版会
  • [Remarks]

    • URL

      http://www.med.keio.ac.jp/rdb/med/view.php?i=32

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Published: 2014-08-29  

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