2011 Fiscal Year Final Research Report
Pathologic analysis of Rett syndrome with the model induced pluripotent stem cells for development of treatment method
| Project/Area Number |
22791009
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Kurume University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 小児神経学 / iPS細胞 |
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| Research Abstract |
In applicant's facilities, the regenerative medicine method and gene therapy in Rett syndrome(RTT) has been developed with the model mouse. Moreover, it has been successful with the establishment of RTT model embryonic stem cells that is knocked out the RTT causative gene MeCP2(methyl-CpG-binding protein 2). In this research, we established the RTT model induced pluripotent stem cells(iPS cells) and analyzed the influence of the MeCP2 mutation for the differentiation and the maturity of the neuronal cells by analysis of the neural cells differentiated from RTT model iPS cells. And, We found the relationship between RTT pathogenesis and the function of glial cells. Therefore, We analyzed the properties of RTT model glial cells.
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