2012 Fiscal Year Final Research Report
Mechanism of NLRR1-regulated signaling pathway and establishment of a novel targeted therapy
| Project/Area Number |
22791016
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Chiba Cancer Center (Research Institute) |
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Principal Investigator |
TAKATORI Atsushi 千葉県がんセンター(研究所), 小児がん研究センター, 研究員 (40455390)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 小児腫瘍学 |
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| Research Abstract |
New and efficient therapeutic strategies are required to improve overall survival for the high-risk neuroblastoma (NB). In the present project, intensive functional analyses have been performed to understand the mechanism of NLRR1-regulated growth signaling pathway. The study demonstrated that NLRR1 enhances proliferative signals rather than differentiating signals through membrane structure of lipid rafts. Functional screening has identified anti-NLRR1 monoclonal antibody harboring growth inhibitory effect, suggesting that a potential therapeutic strategy for NB therapy.
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