2012 Fiscal Year Final Research Report
Development of antiviral treatment for paramyxovirus infection that target the L protein
| Project/Area Number |
22791018
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
SEKI Fumio 国立感染症研究所, ウイルス第三部, 主任研究官 (20443111)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 小児感染症 |
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| Research Abstract |
P protein with a deletion of amino acids between 307 and 336 (Pd307-336) decreased the interaction between P and P, and P and L protein. Expressing the Pd307-336 inhibited the virus growth. Similar effects were obtained when lacking the N-terminal amino acids of the Pd307-336. I was expressed L protein and mutant P proteins using Escherichia coli as a host.
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