2012 Fiscal Year Final Research Report
The effect of HGF on MMP-9 expression in human meningeal cells; Toward the development of novel therapeutic strategies for posthemorrhagic hydrocephalus
| Project/Area Number |
22791024
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 脳室内出血 / 出血後水頭症 / HGF / TGF-betal / MMP-9 / ヒト髄膜細胞 |
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| Research Abstract |
We treated cultured human meningeal cells with human recombinant HGF and TGF-beta1. We found that the expression of MMP-9 was enhanced by HGF, most probably through the activation of the ERK1/2 and PI3K signaling pathways. And more, we found that TGF-beta1 enhances the effect of HGF on MMP-9 expression in human meningeal cells. Our present data may provide an impetus for the development of therapies targeting MMP-9 or HGF, which will eliminate the need for a shunt operation in PHH patients.
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