2011 Fiscal Year Final Research Report
The gene expression profiling of the extramammary Paget's disease, identification of a surface marker and establishment of a cell line
| Project/Area Number |
22791055
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Chiba University |
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Principal Investigator |
TOGAWA Yaei 千葉大学, 大学院・医学研究院, 助教 (90361427)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 皮膚腫瘍学 |
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| Research Abstract |
We reported the efficacy for an observation technique of the Paget's cell with a fluorescence microscope in order to identify advanced lesion and small invasive lesion of extramammary Paget's disease. It was the technique based on histological staining of CEA (Paget's cell), D2-40 (lymph vessel) and Hoechst (nucleus). We also reported the first case of 68-year-old Japanese woman with metastatic HER2-positive extramammary Paget's disease that showed the validity of trastuzumab monotherapy. Trastuzumab has few side effects and is well tolerated for elderly patients. It may become a new choice of the adjubant therapy of this disease.
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