2011 Fiscal Year Final Research Report
Anti-TNF-alpha antibody attenuates cutaneous ischemia-reperfusion injury in a mouse model of pressure ulcer
| Project/Area Number |
22791062
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Kanazawa University |
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Principal Investigator |
SAITO Yuki 金沢大学, 医学系, 助教 (90547168)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 虚血再潅流 / 褥瘡 / TNF-α / iNOS / 接着分子 |
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| Research Abstract |
In a mouse model of cutaneous ischemia-reperfusion injury, local administration of anti-TNF-α antibody and 1400W inhibited expression of inducible nitric oxide synthase and cytotoxicity of TNF-α From that reason, I suggest that anti-TNF-α antibody treatment might prevent the pressure ulcers.
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