2011 Fiscal Year Final Research Report
Investigating the role of sugar chain in skin cancer by analyzing transgenic mouse
| Project/Area Number |
22791069
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Osaka University |
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Principal Investigator |
TERAO Mika 大阪大学, 大学院・医学系研究科, 特任研究員(常勤) (40570669)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 糖転移酵素 / 創傷治癒 / 上皮-間葉系転換 / 有棘細胞がん / 表皮角化細胞 |
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| Research Abstract |
N-Acetylglucosaminyltransferase-V(GnT-V) catalyzes theβ1, 6 branching of N-acetylglucosamine on N-glycans. GnT-V expression is elevated during malignant transformation in various types of cancer. To characterize the biological significance of GnT-V, we established GnT-V transgenic(Tg) mice. Cultured keratinocytes derived from these mice showed enhanced migration, which was associated with changes in E-cadherin localization, and epithelial-mesenchymal transition(EMT). Further, EMT. associated factors snail, twist, and, N-cadherin were upregulated, and cutaneous wound healing was accelerated in vivo.
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Research Products
(10 results)
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[Journal Article] Enhanced Epithelial-Mesenchymal Transition-like Phenotype in N-Acetylglucosaminyltransferase V Transgenic Mouse Skin Promotes Wound Healing2011
Author(s)
Terao M, Ishikawa A, Nakahara S, Kimura A, Kato A, Moriwaki K, Kamada Y, Murota H, Taniguchi N, Katayama I, Miyoshi E
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Journal Title
J Biol Chem
Volume: 286(32)
Pages: 28303-11
Peer Reviewed
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[Journal Article] Overexpression ofα1, 6-fucosyltransferase in hepatoma enhances expression of Golgi phosphoprotein 2 in a fucosylation-independent manner2011
Author(s)
Kawamoto S, Moriwaki K, Nakagawa T, Terao M, Shinzaki S, Yamane-Ohnuki N, Satoh M, Mehta AS, Block TM, Miyoshi E
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Journal Title
Int J Oncol
Volume: 39(1)
Pages: 203-8
Peer Reviewed
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