The investigation for various factors which regulates cutaneous inflammation

2011 Fiscal Year Final Research Report

• Project/Area Number: 22791072
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: Kobe University
• Principal Investigator: FUKUNAGA Atsushi 神戸大学, 医学研究科, 助教 (10467649)
• Project Period (FY): 2010 – 2011
• Keywords: 紫外線 / 接触皮膚炎 / チオレドキシン / NKT細胞 / 制御性T細胞

Research Abstract

The contact hypersensitivity response was suppressed by narrowband UVB irradiation. Epidermal langerhans cells were indispensable for this suppression. In addition, the application of human recombinant thioredoxin inhibited contact hypersensitivity response and a primary irritant dermatitis.

Research Products

• [Journal Article] Rapid Desensitization with Autologous Sweat in Cholinergic Urticaria (2011)
  • Author(s): Kozaru T, Fukunaga A, Taguchi K, Ogura K, Nagano T, Oka M, Horikawa T, Nishigori C.
  • Journal Title: Allergol Int Volume: 60 Pages: 277-81
  • Peer Reviewed
• [Journal Article] Langerhans Cells Serve as Immunoregulatory Cells by Activating NKT Cells (2010)
  • Author(s): Fukunaga A, Khaskhely NM, Ma Y, Sreevidya CS, Taguchi K, Nishigori C, Ullrich SE.
  • Journal Title: Immunol Volume: 185 Pages: 4633-40
  • Peer Reviewed
• [Journal Article] Agents that reverse UV-induced immune suppression affect DNA repair (2010)
  • Author(s): Sreevidya CS, Fukunaga A, Khaskhely NM, Masaki T, Ono R, Nishigori C, Ullrich SE.
  • Journal Title: J Invest Dermatol Volume: 130 Pages: 1428-37
  • Peer Reviewed
• [Journal Article] Non-occupational allergic contact dermatitis from 2-N-octyl-4-isothiazolin-3-one in a Japanese mattress gel-sheet used for cooling (2010)
  • Author(s): Fukunaga A, Nishiyama S, Shimizu H, Nagai H, Horikawa T, Mori A, Inoue N, Sasaki K, Nishigori C.
  • Journal Title: Contact Dermatitis Volume: 62 Pages: 317-8
  • Peer Reviewed
• [Journal Article] Aspirin-intolerant chronic urticaria exacerbated by cutaneous application of a ketoprofen poultice (2010)
  • Author(s): Fukunaga A, Hatakeyama M, Taguchi K, Shimizu H, Horikawa T, Nishigori C.
  • Journal Title: Acta Derm Venereol Volume: 90 Pages: 413-5
  • Peer Reviewed
• [Presentation] The role of cutaneous dendritic cells in narrowband UVB-induced immunosuppression
  • Author(s): Kumiko Taguchi, Atsushi Fukunaga, Kanako Ogura, Chikako Nishigori.
  • Organizer: The 35th Annual Meeting of the Japanese Society for Investigative Dermatology
• [Presentation] Both the elicitation phase of contact hypersensitivity response and irritant dermatitis are suppressed by administration of thioredoxin
  • Author(s): Atsushi Fukunaga, Tatsuya Horikawa, Kanako Ogura, Kumiko Taguchi, Xijun Yu, Yoko Funasaka, Masafumi Takeda, Hajime Nakamura, Junji Yodoi, Chikako Nishigori
  • Organizer: 2010 SID Annual Meeting
• [Presentation] Rho kinase pathway regulates contact hypersensitivity response by regulating DC migration through SHPS-1
  • Author(s): Kanako Ogura, Atsushi Fukunaga, Shuntaro Oniki, Hiroshi Nagai, Hideki Okazawa, Takashi Matozaki, Chikako Nishigori, Tatsuya Horikawa
  • Organizer: The 35th Annual Meeting of the Japanese Society for Investigative Dermatology