2011 Fiscal Year Final Research Report
An effect of Th2 environment on kallikrein expression in keratinocytes and skin barrier
| Project/Area Number |
22791074
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Okayama University |
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Principal Investigator |
MORIZANE Shin 岡山大学, 岡山大学病院, 助教 (80423333)
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| Project Period (FY) |
2010 – 2011
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| Keywords | アトピー性皮膚炎 / カリクレイン / Th2サイトカイン |
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| Research Abstract |
We found that Th2 cytokines, IL-4 and IL-13, increase kallikrein 7 expression and function in keratinocytes. Further, KLK7 protein level in the sera of atopic dermatitis patients significantly correlated with IL-4 amounts in the sera. Our finding describes a link between the Th2 environment and epidermal barrier dysfunction in atopic dermatitis.
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