2011 Fiscal Year Final Research Report
Structural determinant of Humanβ-defensin-3 to stimulate cytokine/chemokine secretion
| Project/Area Number |
22791075
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | ヒトβデフェンシン-3 / αヘリカル / アルギニン / IL-6 / IL-8 |
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| Research Abstract |
Humanβ-defensin-3(HBD-3) possesses an ability to stimulate proinflammatory cytokine/chemokine secretion, which links innate and adaptive immunity, as well as antimicrobial activity. Although we hypothesized thatα-helics in N-terminal is a structural determinant for this function and examined the effect on normal human epidermal keratinocytes to secrete IL-6 and-8, the secretion of IL-6 and-8 was associated with two Arg residues in C-terminal unique motif of HBD-3 not withα-helics.
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