Approaches to the pathogenesis of psoriasis, an intractable human skin disorder

2012 Fiscal Year Final Research Report

• Project/Area Number: 22791078
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: The University of Tokushima
• Principal Investigator: MOURI Yasuhiro 徳島大学, 疾患酵素学研究センター, 助教 (80464353)
• Project Period (FY): 2010 – 2012
• Keywords: 乾癬 / サイトカイン

Research Abstract

Psoriasis is an intractable skin disorder whose pathogenesis is unknown. It is not clear whether autoimmunity is involved in the pathogenesis of psoriasis. Because corneodesmosin (CDSN)-deficient mice show the skin phenotypes resembling human psoriasis, we administered neutralizing antibody against IL-22 into the recipient mice grafted with CDSN-deficient skin. We found no obvious changes in the skin phenotypes by the injection of anti-IL-22 neutralizing antibody. We also need to see, however, whether the concomitant administration of neutralizing antibody against IL-23, a Th17 inflammatory cytokine, would show the same results in order to know to determine further the autoimmune features of psoriasis in the future.

Research Products

• [Journal Article] Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma (2011)
  • Author(s): Mouri, Y., Yano, M.,Shinzawa, M., Shimo, Y., Hirota, F., Nishikawa, Y., Nii, T., Kiyonari, H., Abe, T., Uehara, H., Izumi, K., Tamada, K., Chen, L., Penninger, J.M., Inoue, J., Akiyama, T., and Matsumoto, M
  • Journal Title: J. Immunol Volume: 186 Pages: 5047-5057
  • DOI: doi:10.4049/jimmunol.1003533
  • Peer Reviewed
• [Journal Article] Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation (2010)
  • Author(s): Nishikawa, Y., Hirota, F., Yano, M.,Kitajima, H., Miyazaki, J-i., Kawamoto, H., Mouri, Y., and Matsumoto, M
  • Journal Title: J. Exp. Med Volume: 207 Pages: 963-971
  • DOI: doi:10.1084/jem.20092144
  • Peer Reviewed
• [Presentation] Temporal fate-mapping reveals essential roles of Aire in the maturation program of mTECs (2012)
  • Author(s): Matsumoto, M., Nishikawa, Y., Mouri, Y., Hirota F., and Nishijima, H
  • Organizer: ThymUS 2012
  • Place of Presentation: Trump International Beach Resort, Sunny Isles Beach, USA
  • Year and Date: 20121104-09
• [Presentation] Differential requirement of Aire in two transgenic models for the negative selection of autoreactive thymocytes against self-antigens (2012)
  • Author(s): Mouri, Y., Nishikawa, Y., Nishijima, H, and Matsumoto, M
  • Organizer: 第41回日本免疫学会総会
  • Place of Presentation: 神戸国際会議場(神戸市)
  • Year and Date: 2012-12-06
• [Presentation] モデル自己抗原遺伝子導入トランエウジェニックマウスを用いたAire依存的負の選択機構の解析 (2012)
  • Author(s): 毛利安宏、西川裕美子、西嶋 仁、松本 満
  • Organizer: 第22回 Kyoto T Cell Conference
  • Place of Presentation: 和順会館(京都市)
  • Year and Date: 2012-07-06
• [Presentation] Role of self-antigen expressed by Aire-expressing cells in the negative selection process (2011)
  • Author(s): Matsumoto, M., Mouri, Y., Nishikawa, Y., and Nishijima, H
  • Organizer: 5th International Conference on Autoimmunity: Mechanisms and Novel Treatments
  • Place of Presentation: Knossos Royal Village Conference Center, Hersonissos, Crete, Greece
  • Year and Date: 20110923-28
• [Presentation] Aire-dependent organization of thymic microenvironment for the establishment of self tolerance (2011)
  • Author(s): Matsumoto, M., Nishikawa, Y., Mouri, Y., and Nishijima, H
  • Organizer: EUThyme-Rolduc Meeting
  • Place of Presentation: NH Conference Center, Leeuwenhorst, The Netherlands
  • Year and Date: 20110521-24
• [Presentation] Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma (2011)
  • Author(s): Mouri, Y., Yano, M.,Shinzawa, M., Shimo, Y., Nishikawa, Y., Tamada, K., Chen, L., Penninger, J.M., Inoue, J., Akiyama, T., and Matsumoto, M
  • Organizer: 13thInternational TNF Conference, TNF 2011
  • Place of Presentation: Awaji Yumebutai International Conference Center(淡路市)
  • Year and Date: 20110515-18
• [Presentation] Aire-dependent organization of thymic microenvironment for the establishment of self-tolerance (2011)
  • Author(s): Nishikawa, Y., Mouri, Y., Nishijima, H., and Matsumoto, M
  • Organizer: ESF-JSPS Frontier Science Conference Series for Young Researchers 「Cutting Edge Immunology and its Clinical Application」
  • Place of Presentation: Apollo Hotel de Beyaerd, Hulshort, The Netherlands
  • Year and Date: 20110301-06
• [Presentation] AIRE遺伝子を導入したHeLa細胞における細胞周期依存的なAIREタンパク質のリン酸化 (2011)
  • Author(s): 西嶋 仁、毛利安宏、西川裕美子、松本 満
  • Organizer: 第40回日本免疫学会総会
  • Place of Presentation: 幕張メッセ(千葉市)
  • Year and Date: 2011-11-27
• [Presentation] Negative selectionにおけるAire発現細胞由来自己抗原の役割 (2011)
  • Author(s): 毛利安宏、西川裕美子、西嶋 仁、松本 満
  • Organizer: 第40回日本免疫学会総会
  • Place of Presentation: 幕張メッセ(千葉市)
  • Year and Date: 2011-11-27
• [Presentation] Aire in thymic epithelial cells in the medulla controls developmental process of thymocytes (2010)
  • Author(s): Mouri, Y., Nishikawa, Y., and Matsumoto, M
  • Organizer: 4thInternational Congress of Immunology
  • Place of Presentation: Kobe Portopia Hotel(神戸市)
  • Year and Date: 2010-08-24
• [Presentation] Biphasic Aire expression in early embryos and in medullary thymic epithelial cells prior to end-stage terminal differentiation (2010)
  • Author(s): Nishikawa, Y., Mouri, Y., and Matsumoto, M
  • Organizer: 14thInternational Congress of Immunology
  • Place of Presentation: Kobe Portopia Hotel(神戸市)
  • Year and Date: 2010-08-23
• [Presentation] AIRE and autoimmune disease (2010)
  • Author(s): Matsumoto, M., Nishikawa, Y., Hirota, F. and Mouri, Y
  • Organizer: The 19thInternational Rheumatology Symposium
  • Place of Presentation: Kobe Portopia Hotel(神戸市)
  • Year and Date: 2010-04-23