2011 Fiscal Year Final Research Report
Role of platelets for the function of keratinocytes in dermatitis
| Project/Area Number |
22791081
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
MINEOKA Risa 京都府立医科大学, 医学研究科, 助教 (80464585)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 血小板 / ケラチノサイト / 接触皮膚炎 |
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| Research Abstract |
We have reported that platelets play important roles in pathomechanisms of allergic dermatitis. Keratinocytes in the epidermis are deeply involved in pathomechanisms of allergic dermatitis by expressing adhesion molecules and releasing cytokines. However, the role of platelets for the function of keratinocytes in dermatitis has yet to be clarified. We performed the experiments about the role of platelets on keratinocyte function. The results of our study suggest that platelets may affect the function of keratinocytes, however, we have not shown enough data to clarify the role of platelets on keratinocyte function.
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