2011 Fiscal Year Final Research Report
Analysis of regulatory mechanisms of Notch signaling-induced mast cell maturation and antigen-presenting cell functions
| Project/Area Number |
22791091
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | マスト細胞 / Notchシグナル / MHC class II / mast cell protease |
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| Research Abstract |
Mast cells play an important role in the pathogenesis of allergic inflammatory disorders, such as atopic dermatitis and food allergy. We have previously shown that Notch receptor-mediated signaling contributes to expression of mast cell functions and mast cell maturation. In this study, we elucidated the molecular mechanisms by which Notch signaling induces the antigen-presenting cell functions and the cell maturation in mouse bone marrow-derived mast cells.
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[Journal Article] Role of PU. 1 in MHClassI expressiothrough transcriptional regulation of class II transactivator pI in dendritic cells2012
Author(s)
Kitamura N, Yokoyama H, Yashiro T, Nakano N, Nishiyama M, Kanada S, Fukai T, Hara M, Ikeda S, Ogawa H, Okumura K, Nishiyama C
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Journal Title
J Allergy Clin Immunol
Volume: 129
Pages: 814-824
Peer Reviewed
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[Journal Article] Suppressive effects of transcription factor GATA-1 on cell type-specific gene expression in dendritic cells2010
Author(s)
Shimokawa N, Nishiyama C, Nakano N, Maeda K, Suzuki R, Hara M, Fukai T, Tokura T, Miyajima H, Nakao A, Ogawa H, Okumura K
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Journal Title
Immunogenetics
Volume: 62
Pages: 421-9
Peer Reviewed
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