2011 Fiscal Year Final Research Report
Analysis of IL-33 in inflammatory skin disease
| Project/Area Number |
22791093
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
IMAI Yasutomo 兵庫医科大学, 医学部, 助教 (10529514)
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| Project Period (FY) |
2010 – 2011
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| Keywords | インターロイキン33(IL-33) / 接触過敏反応 / アレルギー |
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| Research Abstract |
IL-33 has been cloned recently as the ligand of ST2. As with IL-1β or IL-18, IL-33 is a member of the IL-1 cytokine family. Effect of IL-33 is dependent on ST2 binding, and its signal is transduced via MyD88, as with IL-1β or IL-18. We examined the role of IL-33 in an immediate type contact hypersensitivity of skin by challenging BALB/c mice with DNFB repeatedly. Wild-type BALB/c mice or ST2-deficient mice were sensitized on shaved back skin with DNFB, and repeatedly challenged with DNFB on the left ear once a week. The ear thickness was measured before and after each challenge. The reactions were hapten specific. Wild-type BALB/c mice showed both immediate and delayed-type reactions, whereas ST2 KO mice did not show any immediate reaction. These results suggest that IL-33 may have an important role in the mechanism of immediate contact hypersensitivity.
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Research Products
(10 results)
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[Journal Article] Knocking-in the R142C mutation in transglutaminase 1 disrupts the stratum corneum barrier and postnatal survival of mice2012
Author(s)
Nakagawa N, Yamamoto M, Imai Y, Sakaguchi Y, Takizawa T, Ohta N, Yagi N, Hatta I, Hitomi K, Takizawa T, Takeda J, Tsuda T, Matsuki M, Yamanishi K
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Journal Title
J Dermatol Sci.
Volume: 65
Pages: 196-206
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[Journal Article] Contribution of IL-18 to eosinophilic airway inflammation induced by immunization and challenge with Staphylococcus aureus proteins2010
Author(s)
Kuroda-Morimoto M, Tanaka H, Hayashi N, Nakahira M, Imai Y, Imamura M, Yasuda K, Yumikura-Futatsugi S, Matsui K, Nakashima T, Sugimura K, Tsutsui H, Sano H, Nakanishi K
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Journal Title
Int Immunol.
Volume: 22
Pages: 561-70
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