2011 Fiscal Year Final Research Report
PD-1 associated immunomodulation and chemokine receptor-derived metastases in malignant melanoma
| Project/Area Number |
22791095
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
HINO Ryosuke 産業医科大学, 医学部, 講師 (30446116)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 悪性黒色腫 / ケモカイン受容体 / 免疫抑制 |
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| Research Abstract |
We found the strong expression of CCR5 on tumor cells obtained from aggressive cases. Our present findings suggest that CCR5 function can relate with migration, TGF-β production, and proliferation of melanoma cells. These findings suggest that the CCR5 and its ligands may promote tumor progression in an autocrine/paracrine manner. In tumor microenvironment, CCR5 plays dual role : promotion of tumor progression or enhancement of tumor immunity. In this study, we focused on CCR5 associated tumor progression. Based on these findings, we conduct further investigation whether CCR5 expression affects the prognosis of malignant melanoma.
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