2012 Fiscal Year Final Research Report
A multifaceted study of brain network in schizophrenia: morphological, physiological and functional approach
| Project/Area Number |
22791116
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | University of Fukui |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 統合失調症 / 脳内ネットワーク / 認知制御 / functional MRI / 脳波 / 非線形解析 / ガンマオシレーション |
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| Research Abstract |
Reliability of fMRI activations with the Stroop task was preliminary investigated in order to assess a potential ability of fMRI is to monitoring the pathogenic progress or therapeutic interventions. The Stroop task can elicit brain activations in anterior cingulate and dorsolateral prefrontal that have a relatively high degree of reproducibility. As for EEG study, changes of cortical function with amphetamine were investigated in schizophrenia and healthy controls using EEG complexity analysis. As a result, amphetamine tends to reduce cortical function in healthy control which was not seen in schizophrenia.
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