2011 Fiscal Year Final Research Report

Effect of treatment for depression on oxidative stress marker and brain-derived neurotrophic factor

Research Project

Project/Area Number	22791117
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Psychiatric science
Research Institution	University of Yamanashi
Principal Investigator	TAMAOKI Toshio 山梨大学, 医学部・附属病院, 助教 (60345709)
Project Period (FY)	2010 – 2011
Keywords	うつ病 / 認知症 / 酸化ストレス / 脳由来神経栄養因子 / コリンエステラーゼ / 栄養状態
Research Abstract	It is pointed out that the depression is related to dementia closely. It may prevent dementia if depression is treated appropriately. Oxidative stress markers and brain-derived neurotrophic factor are related to dementia and depression. I measured an oxidative stress marker and brain-derived neurotrophic factor before and after treatment for depression. As a result, I found that serum brain-derived neurotrophic factor related to the index of nutritional status including serum choline esterase. From this, it was supposed that serum brain-derived neurotrophic factor changed parallel to nutritional status.