2011 Fiscal Year Final Research Report
Angiogenesis, neurogenesis and anti-depressive effect of CD34 positive stem cell transplantation in rat brain.
| Project/Area Number |
22791119
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Psychiatric science
|
|---|
| Research Institution | Hamamatsu University School of Medicine |
|---|
Principal Investigator |
KAMENO Yosuke 浜松医科大学, 医学部, リサーチアシスタント (40537255)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Keywords | 精神生理学 / 血管・神経新生 |
|---|
| Research Abstract |
In recent studies, recovery of cerebral blood flow emerged as a novel therapeutic strategy for depression. To establish animal model for the therapy method research, I tried to transplant CD34 positive hematopoietic stem cell into rat brain through the internal carotid artery and succeeded to confirm its proliferation in the rat brain capillaries after transfusion in this project. However, I regretted to discontinue the project because the survival rate of rat was less than 60% within 1 week after transfusion.
|
