Genome-wide association study of schizophrenia in a Japanese population and follow-up study

2011 Fiscal Year Final Research Report

• Project/Area Number: 22791120
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: Nagoya University
• Principal Investigator: ALEKSIC Branko 名古屋大学, 大学院・医学系研究科, 特任准教授 (60547511)
• Project Period (FY): 2010 – 2011
• Keywords: JGWAS / MAGI2 / 統合失調症 / 認知機能 / 実行機能

Research Abstract

A synapse scaffolding protein, MAGI2, interacts with a variety of functional molecules including glutamate receptors and is presumed to be relevant to cognitive impairment in schizophrenia. In this study, we conducted an association analysis of MAGI2 in schizophrenia and evaluated an effect of this gene on cognitive function. As a result, two polymorphisms(rs2190665、rs4729938) showed suggestive evidence of association with schizophrenia. In addition, rs2190665 was found to be related to impairment of executive function.

Research Products

• [Journal Article] Evaluation of factors affecting Continuous Performance Test Identical Pairs Version score of schizophrenic patients in a Japanese clinical sample Schizophrenia Research and Treatment (2012)
  • Author(s): Koide T, Aleksic B, Kikuchi T, Banno M, Kohmura K, Adachi Y, Kawano N, Iidaka t, Ozaki N.
  • Volume: (In press)
  • Peer Reviewed
• [Journal Article] Genome-wide association study of schizophrenia in a Japanese population (2011)
  • Author(s): Ikeda M, Aleksic B, Kinoshita Y, Okochi T, Kawashima K, Kushima I, Ito Y, Nakamura Y, Kishi T, Okumura T, Fukuo Y, Williams HJ, Hamshere ML, Ivanov D, Inada T, Suzuki M, Hashimoto R, Ujike H, Takeda M, Craddock N, Kaibuchi K, Owen MJ, Ozaki N, O' Donovan
  • Journal Title: Biol Psychiatry Volume: 69(5) Pages: 472-8
  • Peer Reviewed
• [Journal Article] A case control association study and cognitive function analysis of neuropilin and tolloid-like 1 gene and schizophrenia in the Japanese population (2011)
  • Author(s): Banno M, Koide T, Aleksic B, Yamada K, Kikuchi T, Kohmura K, Adachi Y, Kawano N, Kushima I, Ikeda M, Inada T, Yoshikawa T, Iwata N, Ozaki N
  • Journal Title: PLoS One Volume: 6(12) Pages: e28929
  • Peer Reviewed
• [Presentation] Association study and expression analysis between MAGI2 and schizophrenia (2011)
  • Author(s): Koide T, Aleksic B, Yoshimi A, et al.
  • Organizer: Paper presented at :名古屋大学グローバルCOEプログラム機能分子医学への神経疾患・腫瘍の融合拠点第3回国際シンポジウム
  • Place of Presentation: ミッドランドホール、ミッドランドスクエア、名古屋市、日本
  • Year and Date: 20111208-09
• [Presentation] Association study and expression analysis between MAGI2 and schizophrenia (2011)
  • Author(s): Koide T, Aleksic B, Yoshimi A, et al.
  • Organizer: Paper presented at : WCPG 2011, world congress of psychiatric genetics
  • Place of Presentation: Omni Shoreham Hotel, Washintong, DC, United States
  • Year and Date: 20110910-14
• [Presentation] Association study and cognitive function analysis of MAGI2 as a candidate gene for schizophrenia (2011)
  • Author(s): Koide T, Aleksic B, Ikeda M, et al.
  • Organizer: Paper presented at : WFSBP 2011 : world congress of biological psychiatry
  • Place of Presentation: Prague, Czech Republic
  • Year and Date: 20110529-0602