The Mechanism of neuroplasticity for discovery of antidepressants

2011 Fiscal Year Final Research Report

• Project/Area Number: 22791127
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: Yamaguchi University
• Principal Investigator: YAMAGATA Hirotaka 山口大学, 大学院・医学系研究科, 助教 (10549934)
• Project Period (FY): 2010 – 2011
• Keywords: 精神薬理学

Research Abstract

Antidepressant treatment has been reported to increase neurogenesis and neural plasticity in the hippocampus. In this study, we focused on BubR1. The mRNA of BubR1 was decreased with chronic antidepressant treatment in the hippocampus the model mice for depression. Silencing of BubR1 accelerated neurite outgrowth in Neuro2a and SH-SY5Y cells. Exogenous expression of BubR1 inhibited neurite outgrowth in Neuro2a cells and primary neuron. These results suggest that BubR1 might be involved in the neural plasticity and the effect of antidepressant.

Research Products

• [Journal Article] State-dependent changes in the expression of DNA methyltransferases in mood disorder patients (2011)
  • Author(s): Higuchi F, Uchida S, Yamagata H, Otsuki K, Hobara T, Abe N, Shibata T, Watanabe Y
  • Journal Title: J Psychiatr Res Volume: 45 Pages: 1295-300
  • Peer Reviewed
• [Journal Article] Altered sirtuin deacetylase gene expression in patients with a mood disorder (2011)
  • Author(s): Abe N, Uchida S, Otsuki K, Hobara T, Yamagata H, Higuchi F, Shibata T, Watanabe Y
  • Journal Title: J Psychiatr Res Volume: 45 Pages: 1106-12
  • Peer Reviewed
• [Journal Article] Impaired hippocampal spinogenesis and neurogenesis and altered affective behavior in mice lacking heat shock factor 1 (2011)
  • Author(s): Uchida S, Hara K, Kobayashi A, Fujimoto M, Otsuki K, Yamagata H, Hobara T, Abe N, Higuchi F, Shibata T, Hasegawa S, Kida S, Nakai A, Watanabe Y
  • Journal Title: Proc Natl Acad Sci USA Volume: 108 Pages: 1681-6
  • Peer Reviewed
• [Journal Article] Epigenetic status of Gdnf in the ventral striatum determines susceptibility and adaptation to daily stressful events (2011)
  • Author(s): Uchida S, Hara K, Kobayashi A, Otsuki K, Yamagata H, Hobara T, Suzuki T, Miyata N, and Watanabe Y
  • Journal Title: Neuron Volume: 69 Pages: 359-72
  • Peer Reviewed
• [Journal Article] Early life stress enhances behavioral vulnerability to stress through the activation of REST4-mediated gene transcription in the medial prefrontal cortex of rodents (2010)
  • Author(s): Uchida S, Hara K, Kobayashi A, Funato H, Hobara T, Otsuki K, Yamagata H, McEwen BS, Watanabe Y
  • Journal Title: J Neurosci Volume: 30 Pages: 15007-18
  • Peer Reviewed
• [Presentation] BubR1 inhibits neurite outgrowth of neuroblastoma cells (2011)
  • Author(s): Hirotaka Yamagata et al
  • Organizer: Neuroscience 2011
  • Place of Presentation: Washington, DC. USA
  • Year and Date: 2011-11-14
• [Presentation] エピジェネティクスとストレス脆弱性、うつ病 (2011)
  • Author(s): 山形弘隆, 他
  • Organizer: 第54回日本神経化学学会
  • Place of Presentation: 瑠璃光(金沢市)
  • Year and Date: 2011-09-27
• [Presentation] BubR1はニューロブラストーマ細胞の神経突起伸展を制御している (2011)
  • Author(s): 山形弘隆, 他
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2011-09-17
• [Presentation] うつ病と神経可塑性に対するBubR1の役割 (2010)
  • Author(s): 山形弘隆, 他
  • Organizer: 第32回日本生物学的精神医学会
  • Place of Presentation: リーガロイヤルホテル小倉(北九州市)
  • Year and Date: 20101007-09