An i nvest i gat i on i nto the cause of and i tory ha I I uc i nat i on and and i tory information processing deficits in schizophrenia

2011 Fiscal Year Final Research Report

• Project/Area Number: 22791129
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: Kyushu University
• Principal Investigator: HIRANO Yoji 九州大学, 医学研究院, 学術研究員 (90567497)
• Research Collaborator: KANBA Shigenobu 九州大学, 医学研究院, 教授 (50195187) ; ONITSUKA TOSHIAKI 九州大学, 大学病院, 講師 (00398059) ; KASAI Kiyoto 東京大学, 医学部付属病院, 教授 (80322056) ; UENO Takefumi 九州大学, 医学研究院, 特任准教授 (00441668) ; HIRANO Shogo 九州大学, 医学研究院, 共同研究員 (10568984) ; ORIBE Naoya 九州大学, 医学研究院, 学術研究員 ; NAKAMURA Itta 九州大学, 医学研究院, 大学院生 ; SPENCER Kevin M. HARVARD MEDICAL SCHOOL, Vamc, Associate Professor ; MCCARLEY Robert W. HARVARD MEDICAL SCHOOL, Vamc, Professor
• Project Period (FY): 2010 – 2011
• Keywords: 統合失調症 / 幻聴 / Auditory information processing / Audio-Visual integration / 脳磁図 / 脳波 / 時間周波数解析

Research Abstract

The aim of this study was to investigate the neural basis of auditory hallucination in schizophrenia. We analyzed the neural activities related to auditory hallucinations or the audio-visual integration process using new neurophysiological methods. We found that abnormalγ-band neural oscillation activities evoked during audio, visual and audio-visual integration were prominently involved in the neural basis of auditory hallucinations in schizophrenia. These results may contribute to the development of diagnoses, therapies and provide clues to the underlying cause of schizophrenia.

Research Products

• [Journal Article] Altered face inversion effect and association between face N170 reduction and social dysfunction in patients with schizophrenia (2012)
  • Author(s): Tsunoda T, Kanba S, Ueno T, Hirano Y, Hirano S, Maekawa T, Onitsuka T
  • Journal Title: Clinical Neurophysiology Volume: in press
  • Peer Reviewed
• [Journal Article] Reduced high and low frequency gamma synchronization in patients with chronic schizophrenia (2011)
  • Author(s): Tsuchimoto R, Kanba S, Hirano S, Oribe N, Ueno T, Hirano Y, Nakamura I, Oda Y, Miura T, Onitsuka T
  • Journal Title: Schizophrenia Research Volume: 133 Pages: 99-105
  • Peer Reviewed
• [Journal Article] Spatiotemporal signatures of an abnormal auditory system in stuttering (2011)
  • Author(s): Kikuchi Y, Ogata K, Umesaki T, Yoshiura T, Kenjo M, Hirano Y, Okamoto T, Komune S, Tobimatsu S
  • Journal Title: Neuroimage Volume: 55 Pages: 891-899
  • Peer Reviewed
• [Journal Article] Stability of the Rayleigh distribution (2011)
  • Author(s): Ueno T, Hirano S, Hirano Y, Oribe N, Nakamura I, Oda Y, Kanba S, Onitsuka T
  • Journal Title: Proc Inter Cong Imaging and Signal Processing IEEE Volume: 5 Pages: 2402-2403
  • Peer Reviewed
• [Journal Article] 統合失調症の顔認知障害と社会機能障害の関連 (2011)
  • Author(s): 鬼塚俊明, 大林長二, 角田智哉, 平野昭吾, 平野羊嗣, 前川敏彦, 上野雄文
  • Journal Title: 認知神経科学 Volume: 13 Pages: 64-70
  • Peer Reviewed
• [Journal Article] Differentiation between bipolar disorder and schizophrenia revealed by neural oscillation to speech sounds : an MEG study (2010)
  • Author(s): Oribe N, Onitsuka T, Hirano S, Hirano Y, Maekawa T, Obayashi C, Ueno T, Kasai K, Kanba S
  • Journal Title: Bipolar Disorder Volume: 12 Pages: 804-812
  • Peer Reviewed
• [Journal Article] Auditory gating deficit to human voices in schizophrenia : a MEG study (2010)
  • Author(s): Hirano Y, Hirano S, Maekawa T, Obayashi C, Oribe N, Monji A, Kasai K, Kanba S, Onitsuka T
  • Journal Title: Schizophrenia Reseach Volume: 117 Pages: 61-67
  • Peer Reviewed
• [Presentation] Visual P300 deficits in individuals in prodromal state and first episode schizophrenia (2012)
  • Author(s): Oribe N, Niznikiewicz M, Hirano Y, E. C. del Re, Tasoff T, Spencer KM, McCarleyRW
  • Organizer: Society of Biological Psychiatry 67th Annual Meeting
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 2012-05-05
• [Presentation] Functional and Structural Evidence (2012)
  • Author(s): Hirano Y, Quan M, Niznikiewicz M, McCarley RW, Spencer KM : Abnormalγ-band Auditory Steady-State Responses in Schizophrenia
  • Organizer: Society of Biological Psychiatry 67th Annual Meeting
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 2012-05-03
• [Presentation] Aberrant Gamma-band Auditory Responses in Chronic Schizophrenia (2012)
  • Author(s): Hirano Y, Quan M, Niznikiewicz M, McCarley RW, Spencer KM
  • Organizer: 012 McGovern MEG Symposium
  • Place of Presentation: Cambridge, USA
  • Year and Date: 2012-04-27
• [Presentation] Possible preattentive dysfunction in patients with bipolar disorder : MEG study (2012)
  • Author(s): Oribe N and Hirano Y
  • Organizer: 2012 McGovern MEG Symposium
  • Place of Presentation: Cambridge, USA
  • Year and Date: 2012-04-27
• [Presentation] Abnormal Gamma-band Auditory Steady-State Responses in Chronic Schizophrenia (2012)
  • Author(s): Hirano Y, Quan M, Niznikiewicz M, McCarley RW, Spencer KM
  • Organizer: 2012 Mysell Research Meeting
  • Place of Presentation: Boston, USA
  • Year and Date: 2012-03-28
• [Presentation] Visual P300 deficits in individuals in prodromal state and first episode schizophrenia (2012)
  • Author(s): Oribe N and Hirano Y, Tasoff T, Spencer KM, Niznikiewicz M, McCarley RW
  • Organizer: 2012 Mysell Research Meeting
  • Place of Presentation: Boston, USA
  • Year and Date: 2012-03-28
• [Presentation] Electrophysiological and GABA and Glutamate MRS Measures in SPD : Preliminary Results (2012)
  • Author(s): E. C. del Re and Hirano Y, Lin A, Voglmaier M, Oribe N, Tasoff T, Spencer KM, Niznikiewicz M, McCarley RW
  • Organizer: 2012 Mysell Research Meeting
  • Place of Presentation: Boston, USA
  • Year and Date: 2012-03-28
• [Presentation] Audio-visual multimodal integration activity in human brain : An MEG study (2011)
  • Author(s): Nakamura I and Hirano Y, Ohara N, Oribe N, Hirano S, Ueno T, Onitsuka T
  • Organizer: Neuroscience 2011
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2011-11-14
• [Presentation] Face processing deficits and social dysfunction in schizophrenia : A magnetoencephalography study (2011)
  • Author(s): Ohara N, Kanba S, Ueno T, Hirano Y, Hirano S, Oribe N, Onituka T
  • Organizer: Neuroscience 2011
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2011-11-14
• [Presentation] 統合失調症における高周波数帯域γ同期性の減少 (2011)
  • Author(s): 土本利架子,神庭重信,平野昭吾,織部直弥,上野雄文,平野羊嗣,中村一太,小田祐子, 三浦智史,鬼塚俊明
  • Organizer: 第11回精神疾患と認知機能研究会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-05
• [Presentation] Reduced high frequency gamma synchronization and auditory hallucination symptoms in schizophrenia (2011)
  • Author(s): Tsuchimoto R, Hirano S, Oribe N, Ueno T, Hirano Y, Nakamura I, Oda Y, Onitsuka T, Kanba S
  • Organizer: Human Brain Mapping 2011
  • Place of Presentation: Quebeq, Canada
  • Year and Date: 2011-06-29
• [Presentation] Auditory sensory gating deficit to voices in psychotic bipolar disorder : a MEG study (2010)
  • Author(s): Hirano Y, Hirano S, Oribe N, Maekawa T, Tsunoda T, Nakamura I, Tsuchimoto R, Ueno T, Ninomiya H, Onitsuka T, Kanba S
  • Organizer: 29th International Congress of Clinical Neurophysiology
  • Place of Presentation: Kobe, Japan
  • Year and Date: 20101028-11
• [Book] 現代精神医学事典 (2011)
  • Author(s): 加藤敏ら編(分担:平野羊嗣)
  • Total Pages: 1400
  • Publisher: 弘文堂
• [Book] 脳科学エッセンシャル-精神疾患の生物学的理解のために.専門医のための精神科臨床リュミエール16 :脳磁図と精神疾患
  • Author(s): 神庭重信ら編(分担:平野羊嗣)
  • Total Pages: 253-256
  • Publisher: 中山書店
• [Remarks] ホームページ:(担当管理:平野羊嗣)
  • URL: http://www.med.kyushu-u.ac.jp/psychiatry/