2011 Fiscal Year Final Research Report
Biomarker for diagnosis of Dementia with Lewy bodies.
| Project/Area Number |
22791134
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 老年精神医学 / 認知症 |
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| Research Abstract |
The apolipoprotein E(APOE)ε4 allele has been reported to be a risk factor for Alzheimer's disease(AD) and dementia with Lewy bodies(DLB). Previous neuropathological studies have demonstrated similar frequencies of the APOEε4 allele in AD and DLB. However, the few ante-mortem studies on APOE allele frequencies in DLB have shown lower frequencies than post-mortem studies. One reason for this may be inaccuracy of diagnosis. We examined APOE genotypes in subjects with AD, DLB, and a control group using the latest diagnostic criteria and MRI, SPECT, and MIBG myocardial scintigraphy. The rate of APOE4 carrier status was 18. 3% and the frequency of theε4 allele was 9. 7% in controls. The rate of APOE4 carrier status and the frequency of theε4 allele were 47% and 27% for LOAD, 50% and 31% for EOAD, and 42% and 31% for DLB, respectively. The APOE4 genotypes in this study are consistent with previous neuropathological studies suggesting accurate diagnosis of AD and DLB. APOE4 genotypes were similar in AD and DLB, giving further evidence that theε4 allele is a risk factor for both disorders.
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[Journal Article] Investigation of annexin A5 as a biomarker for alzheimer's disease using Neuronal cell culture and mouse model2011
Author(s)
Yamaguchi M, Kokai Y, Imai S, Utsumi K, Matsumoto K, Honda H, Mizue Y, Momma M, Maeda T, Toyomasu S, Ito YM, Kobayashi S Hashimoto E, Saito T, Sohma H
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Journal Title
J Neurosci Res
Volume: 18
Pages: 2682-2692
Peer Reviewed
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