Study on disability of the acoustic sense memory in adult with slightly developmental disorder

2013 Fiscal Year Final Research Report

• Project/Area Number: 22791136
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: Fukushima Medical University
• Principal Investigator: ITAGAKI Shuntaro 福島県立医科大学, 医学部, 講師 (80457788)
• Project Period (FY): 2010-10-20 – 2014-03-31
• Keywords: 事象関連電位 / 注意欠陥多動障害 / 広汎性発達障害 / 統合失調症 / ミスマッチ陰性電位 / Nd / N2ｂ / P300

Research Abstract

Event-related potentials (ERPs) such as Nd, N2b, and P300 were compared among 54 adult AD/HD patients, 43 schizophrenic patients (SZ), and 40 healthy age-matched volunteers (HC). It is known that Nd, N2b, and P300 reflect selective attention, voluntary attention, and cognitive context updating respectively. The peak amplitude of P300 was significantly lower in the adult AD/HD and SZ groups than in the HC group. The peak latencies of late Nd, N2b, and P300 were significantly longer in the SZ group than in the HC and adult AD/HD groups. Thus, attenuated amplitude and prolonged latency of various ERP components in the SZ group suggest the possibility of impairment of basic mechanisms underlying cognitive processing. Unlike the SZ group, the adult AD/HD group exhibited reduced amplitude of P300 but not prolonged latency. These findings suggest the existence of a different type of cognitive dysfunction in the adult AD/HD group, which might be closely related to attentional function.

Research Products

• [Journal Article] Event-related potentials in patients with adult attention-deficit/ hyperactivity disorder versus schizophrenia (2011)
  • Author(s): Shuntaro Itagaki, Hirooki Yabe, Yukiko Mori, Hiromichi Ishikawa, Yasuko Takanashi, Shin-ichi Niwa
  • Journal Title: Psychiatry Research Volume: 189 Pages: 288-291
  • Peer Reviewed
• [Journal Article] 臨床医学の展望2010 (2010)
  • Author(s): 丹羽真一, 矢部博興, 小林直人, 板垣俊太郎, 竹内賢, 池本桂子, 境洋二郎, 増子博文, 國井泰人, 管るみ子, 山本佳子, 和田明
  • Journal Title: 精神医学 日本医事新報 Volume: 4492 Pages: 60-67
• [Journal Article] 現時点での十八歳以上成人ADHDの診断と治療 (2010)
  • Author(s): 板垣俊太郎, 増子博文, 丹羽真一
  • Journal Title: 現代のエスプリ Volume: 513 Pages: 63-69
• [Presentation] 成人期注意欠陥多動障害患者における塩酸メチルフェニデート投薬によるミスマッチ陰性電位(mismatch negativity : MMN)の変化 (2013)
  • Author(s): 板垣俊太郎, 矢部博興, 松岡貴志, 疋田雅之, 志賀哲也, 野崎途也, 大島洋和, 浅野聡子, 刑部有祐, 丹羽真一
  • Organizer: 第43回日本臨床神経生理学会学術大会
  • Place of Presentation: 高知
  • Year and Date: 20131107-09
• [Presentation] 「シンポジウム 3」精神障害の病態解明への神経生理学の貢献「精神障害診断バッテリーPsycopros-F08の取り組みについて」 (2013)
  • Author(s): 板垣俊太郎, 志賀哲也, 河野創一, 野崎途也, 浅野聡子, 伊藤典和, 刑部有祐, 松岡貴志, 菅野和子, 押山千秋, 堀越翔, 大島祥恵, 野崎啓子, 森由紀子, 後藤大介, 三浦至, 疋田雅之, 増子博文, 丹羽真一, 矢部博興
  • Organizer: 第43回日本臨床神経生理学会学術大会
  • Place of Presentation: 高知
  • Year and Date: 20131107-09
• [Presentation] Mismatch Negativity (MMN) in Patients with Adult Attention-Deficit/Hyperactivity Disorder (2012)
  • Author(s): 板垣 俊太郎
  • Organizer: 第42回日本臨床神経生理学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 20121108-10
• [Presentation] Mismatch Negativity (MMN) in Patients with Adult Attention-Deficit/Hyperactivity Disorder (2012)
  • Author(s): Shuntaro Itagaki, Hirooki Yabe, Tetsuya Shiga, Michinari Nozaki, Shin-ichi Niwa
  • Organizer: The 6th Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Application
  • Place of Presentation: NYC
  • Year and Date: 20120501-05
• [Presentation] MMNと発達障害 (2011)
  • Author(s): 板垣俊太郎, 三浦祥恵, 野崎途也, 于楽,志賀哲也, 菅野 和子, 矢部博興, 丹羽真一
  • Organizer: 第41回日本臨床神経生理学会学術大会
  • Place of Presentation: 静岡
  • Year and Date: 2011-11-11