2011 Fiscal Year Final Research Report
Predicting plasma concentration of risperidone associated with dosage change : a population pharmacokinetic study
| Project/Area Number |
22791140
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Keio University |
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Principal Investigator |
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| Research Collaborator |
BIES Robert R. Indiana University School of Medicine, Division of Clinical Pharmacology, 准教授
MAMO David University of Toronto, Department of Psychiatry, 准教授
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| Project Period (FY) |
2010 – 2011
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| Keywords | 血中濃度 / 抗精神病薬 / 統合失調症 |
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| Research Abstract |
The present study, including50patients with schizophrenia, demonstrated that antipsychotic plasma concentrations of risperidone and its active moiety can be predicted before performing an actual dosage change, using population pharmacokinetic techniques. These findings suggest that individualized dosing with the measurement of antipsychotic plasma concentrations could become a real clinical application in the management of schizophrenia.
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Research Products
(11 results)
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[Journal Article] Dopamine D2receptor occupancy and cognition in schizophrenia : analysis of the CATIE data2012
Author(s)
Sakurai H, Bies RR, Stroup SE, Keefe RSE, Rajji TK, Suzuki T, Mamo DC, Pollock BG, Watanabe K, Mimura M, Uchida H
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Journal Title
Schizophr Bull
Volume: (in press)
Peer Reviewed
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[Journal Article] A cross-sectional study of plasma risperidone levels with risperidone long-acting injectable : Implications for dopamine D2receptor occupancy during maintenance treatment in schizophrenia2012
Author(s)
Ikai S, Remington G, Suzuki T, Takeuchi H, Tsuboi T, Den R, Hirano J, Tsunoda K, Nishimoto M, Watanabe K, Mimura M, Mamo DC, Uchida H
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Journal Title
J Clin Psychiatry
Volume: (in press)
Peer Reviewed
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