Thought disorder in schizophrenia on functional MRI study

2011 Fiscal Year Final Research Report

• Project/Area Number: 22791143
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: Tamagawa University
• Principal Investigator: MATSUDA Tetsuya 玉川大学, 脳科学研究所, 准教授 (30384720)
• Project Period (FY): 2010 – 2011
• Keywords: 統合失調症 / fMRI / 思考障害 / 自動処理 / 大脳基底核

Research Abstract

Efforts to localize neural activity associated with self-and other-referential processing have described the activity in the medial prefrontal cortex(mPFC), the anterior cingulate cortex(ACC), and the anterior insula for self-versus other-referencing and activity in the precuneus for other-versus self-referencing. We therefore explored differences in brain activity between patients with schizophrenia and normal controls using functional magnetic resonance imaging(fMRI). Normal controls showed higher activation of the anterior insula, which is associated with self-reflection, whereas patients with schizophrenia showed higher activation of the precuneus, an area associated with other-reflection, even though they were contemplating the correctness of their own answers. These results indicate that patients with schizophrenia may perceive themselves not as self but as other, even during tasks requiring them to reflect on themselves.

Research Products

• [Journal Article] Neural circuits in the brain that are activated when mitigating criminal sentences (2012)
  • Author(s): Yamada M, Camerer CF, Fujie S, Kato M, Matsuda T, Takano H, Ito H, Suhara T, Takahashi H
  • Journal Title: Nature Communications Volume: 3 Pages: 759
  • DOI: DOI:10.1038/ncomms1757
  • Peer Reviewed
• [Journal Article] Eye gaze during observation of static faces in deaf people (2011)
  • Author(s): Watanabe K, Matsuda T, Nishioka T, Namatame M
  • Journal Title: PloS ONE Volume: 6(2) Pages: 216919
  • DOI: DOI:10.1371/journal.pone.0016919
  • Peer Reviewed
• [Journal Article] Functional magnetic resonance imaging study on the effects of acute single administration of paroxetine on motivation-related brain activity (2011)
  • Author(s): Marutani T, Yahata N, Ikeda Y, Ito T, Yamamoto M, Matsuura M, Matsushima E, Okubo Y, Suzuki H, Matsuda T
  • Journal Title: Psychiatry and Clin. Neurosci Volume: 65(2) Pages: 191-198
  • DOI: DOI:10.1111/j.1440-1819.2011.02189.x
  • Peer Reviewed
• [Journal Article] 統合失調症の意思決定障害 (2011)
  • Author(s): 松田哲也、伊藤岳人、鈴木春香、丸谷俊之、松島英介、小島卓也
  • Journal Title: 日本生物学的精神医学会誌 Volume: 22(4) Pages: 257-261
• [Presentation] 統合失調症のセルフリフレクション障害 (2011)
  • Author(s): 松田哲也
  • Organizer: 第33回日本生物学的精神医学会
  • Place of Presentation: シンポジウム
  • Year and Date: 2011-05-22
• [Presentation] Dysfunction of self-reflection in schizophrenia : A functional MRI study (2011)
  • Author(s): Matsuda T, Takahashi S, Nemoto Y, Suzuki M, Ito T, Yamamoto M, Marutani T, Takahashi H, Matsuura M, Matsushima E, Uchiyama M, Kojima T
  • Organizer: American Psychiatric Association
  • Place of Presentation: Hawaii
  • Year and Date: 2011-05-16
• [Remarks]
  • URL: http://web.me.com/matspsyc/HOME.html