2011 Fiscal Year Final Research Report
Prefrontal dysfunction in Attention-deficit/hyperactivity disorder : a NIRS study
| Project/Area Number |
22791148
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Kinki University |
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Principal Investigator |
TSUJII Noa 近畿大学, 医学部, 講師 (90460914)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 児童期 / ADHD / NIRS / methylphenidate |
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| Research Abstract |
The aim of the study is to evaluate the effects of methylphenidate on brain functions in children with attention-deficit/hyperactivity disorder using a near-infrared spectroscopy. Nine children with attention-deficit/hyperactivity disorder(ADHD) participated in the study after giving consent. The evaluation of the treatment effects of MPH were also evaluated with stop-signal task. The hemoglobin concentration changes were measured with frontal probes every 0.1 s during the verbal fluency task using 47-channel NIRS machines. The oxy-Hb concentration changes in the inferior prefrontal lobe during VFT(40-60s) were significantly correlated with SSRT(r=-.69, p=.039). The NIRS machine might be useful for the evaluation for the treatment effects of MPH in children with ADHD.
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