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2011 Fiscal Year Final Research Report

Investigation of the mechanism of metabotropic glutamate receptor 5 activity which protein related to psychiatric disorder.

Research Project

  • PDF
Project/Area Number 22791149
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionKurume University

Principal Investigator

UEMATSU Ken  久留米大学, 医学部, 助教 (60441672)

Project Period (FY) 2010 – 2011
Keywords精神薬理学 / 分子生物学 / 細胞内情報伝達 / 蛋白リン酸化修飾 / 細胞内カルシウム動態
Research Abstract

In this research, we discovered new phosphorylation site of mGluR5, which phosphorylated by PKA and the site is serine 870 of mGluR5. Methods of this study, we generate mGluR5 C-teerminal peptie for in vitro phosphorylation assay by protein kinase A and【γ-32P】ATP. Compared with wild and mutant mGluR5 C-terminal peptide, mutant inhibited to gain【γ-32P】labeled isotope. Now we set up the experiment of the function by this mGluR5 phosphorylation.

  • Research Products

    (1 results)

All 2011

All Presentation (1 results)

  • [Presentation] スフィンゴシン-1-リン酸による線条体中型有棘細胞でのGPR6ひ依存性のPKA/DARPP-32シグナル伝達の解析2011

    • Author(s)
      上松謙, 内村直尚, 松石豊次郎, 西昭徳
    • Organizer
      日本神経科学会
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-24

URL: 

Published: 2013-07-31  

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