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2011 Fiscal Year Final Research Report

Search for biomarkers of bipolar disorder

Research Project

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Project/Area Number 22791152
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

KAZUNO An-a  独立行政法人理化学研究所, 精神疾患動態研究チーム, リサーチアソシエイト (40360523)

Project Period (FY) 2010 – 2011
Keywords脳神経疾患 / 双極性障害 / バイオマーカー
Research Abstract

To search for biomarker of bipolar disorder, we extracted proteins derived from lymphoblastoid cells of monozygotic twins discordant for bipolar disorder and compared protein levels between patients with bipolar disorder and co-twin using two-dimensional fluorescence difference gel electrophoresis. Using antibodies against a part of proteins identified, we performed the case-control study by using western blot analysis. We identified a glycolysis related protein that is different expression levels between patients and healthy controls. The protein may be a biomarker of bipolar disorder.

  • Research Products

    (6 results)

All 2012 2011 2010 Other

All Journal Article (1 results) Presentation (4 results) Remarks (1 results)

  • [Journal Article] Hypermethylation of serotonin transporter gene in bipolar disorder detected by epigenome analysis of discordant monozygotic twins2011

    • Author(s)
      Sugawara H, Iwamoto K, Bundo M, Ueda J, Miyauchi T, Komori A, Kazuno AA, Adati N, Kusumi I, Okazaki Y, Ishigooka J, Kojima T, Kato T
    • Journal Title

      Translational Psychiatry

      Volume: 1 Pages: e24

  • [Presentation] Hypermethylation of serotonin transporter gene in bipolar disorder detected by epigenome analysis of discordant monozygotic twins2012

    • Author(s)
      Sugawara H, Iwamoto K, Bundo M, Ueda J, Miyauchi T, Komori A, Kazuno A, Adati N, Kusum I, Okazaki Y, Ishigooka J, Kojima T, Kato T
    • Organizer
      5th Biennial Conference of the International Society for Bipolar Disorders
    • Place of Presentation
      Turkey, Istanbul
    • Year and Date
      2012-03-15
  • [Presentation] 一卵性双生児双極性障害不一致例におけるリンパ芽球由来ミトコンドリアのプロテオミクス解析2011

    • Author(s)
      数野安亜、岡崎祐士、加藤忠史
    • Organizer
      第33回日本生物学的精神医学会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-22
  • [Presentation] 一卵性双生児双極性障害不一致例におけるゲノム差異およびエピゲノム差異の探索2011

    • Author(s)
      菅原裕子、岩本和也、文東美紀、上田順子、宮内妙子、小森敦子、数野安亜、足立直樹、久住一郎、岡崎祐士、石郷岡純、小島俊男、加藤忠史
    • Organizer
      第33回日本生物学的精神医学会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-22
  • [Presentation] Mitochondrial proteomic analysis of lymphoblastoid cells derived from patients with bipolar disorder2010

    • Author(s)
      Kazuno A, Okazaki Y, Kato T
    • Organizer
      XVIII World Congress on Psychiatric Genetics
    • Place of Presentation
      Greece, Athens
    • Year and Date
      2010-10-05
  • [Remarks]

    • URL

      http://www.riken.jp/index_j.html

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Published: 2013-07-31  

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