2011 Fiscal Year Final Research Report
Understanding the pathology of epilepsy through the regulation of endoplasmic reticulum calcium homeostasis
| Project/Area Number |
22791154
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
SUZUKI Toshimitsu 独立行政法人理化学研究所, 神経遺伝研究チーム, 研究員 (20373318)
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| Project Period (FY) |
2010 – 2011
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| Keywords | てんかん / EFHC1 / IP3レセプター / 小胞体カルシウム |
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| Research Abstract |
We found that myoclonin1 modulates ER-Ca^<2+> homeostasis through interaction with C-terminal of IP_3R1.Our results suggest that impaired intracellular Ca^<2+> mobilization may be the molecular basis for epilepsy caused by EFHC1 mutations.
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